Summary
Physiological saline solution was infused in 9 normal subjects and 6 patients with central diabetes insipidus (DI). At 120 min after the start of infusion, arginine vasopressin (AVP) was injected (i.m.). Urine was collected every 30 min fraction. The urinary excretion of kallikrein-like activity (KAL-A) (S-2266 hydrolysis activity) was significantly lower in patients with DI than in normal subjects, without showing the differences of plasma renin activity (PRA), plasma aldosterone concentration (PAC), creatinine clearance (Ccr) and blood pressure between the two groups, except a marked water-diuresis in DI. The urinary excretion of KAL-A correlated positively with the urinary excretion of AVP. AVP administration significantly increased the urinary excretion of KAL-A. After overnight fasting, an acute oral water-loading was carried out for 15 min in 6 normal subjects. Concomitant with a significant suppression of the level of plasma AVP from the first 30 min, a slight, but significant, decrease in urinary excretion of KAL-A was observed in the first 30 min fraction after loading, compared with the control period. Afterwards, the urinary excretion of KAL-A increased prominantly with an increase in urine flow. KAL-A in the urine decreased promptly from the first 30 min fraction and then gradually until 120 min after loading. Urine volume and free-water markedly increased except the first 30 min fraction, compared with the control period. Thus it is suggested that AVP is one of factors which actually regulate the secretion of renal kallikrein in man.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
G. Fejes-Toth, T. Zahajszky, and J. Filep, Effect of vasopressin on renal kallikrein excretion, Am J. Physiol. 239: F388 (1980).
G. L. Robertson and M. L. Conder, The regulation of urinary kinin excretion, in: “Hormonal Regulation of Sodium Excretion,” B. Lichardus, R. W. Schrier and J. Ponec, eds., Elsevier/North-Holland Biomedical Press, Amsterdam (1980).
M. L. Kauker, J. T. Crofton, L. Share, and A. Nasjletti, Role of vasopressin in regulation of renal kinin excretion in long-evans and diabetes insipidus rats, J. Clin. Invest. 73: 824 (1984).
H. Sakurai, F. Kurimoto, A. Kanai, H. Ohno, K. Nomura, H. Demura, and K. Shizume, A simple and highly sensitive radioimmunoassay for 8-arginine vasopressin in human plasma using an ODS microcolumn technique, 7th International Congress of Endocrinology, Canada, Page 1319 (Abstr.) (1984).
M. Miller, T. Dalakos, A. M. Moses, H. Fellerman, and D. H. P. Streeten, Recognition of partial defects in antidiuretic hormone secretion, Ann Intern. Med. 73: 721 (1970).
R. Geiger and H. Fritz, Human urinary kallikrein, in: “Methods in Enzymology,” L. Lorand, ed., Academic Press, New York (1981).
I. H. Mills and P. E. Ward, The relationship between kallikrein and water excretion and the conditional relationship between kallikrein and sodium excretion, Journal f physiology (London) 246: 695 (1975).
O. A. Carretero and A. G. Scicli, Renal kallikrein: its localization and possible role in renal function, Federationroc. 35: 194 (1976).
I. H. Mills, Kallikrein, kininogen and kinins in control of blood pressure, Nephron 23: 61 (1979).
K. Tomita, T. Shiigai, H. Saito, Y. Iino, and T. Takeuchi, Increased urinary kallikrein-like activity during ADH-induced hyponatremia in rats, Hypertension 6: 511 (1984).
K. Tomita, T. Shiigai, M. Shichiri, R. Andou, T. Shinoda, and J. Takeuchi, Increased urinary kallikrein-like activity in the syndrome of inappropriate secretion of antidiuretic hormone, Nephron 35: 39 (1983).
K. Nustad, The relationship between kidney and urinary kininogenase, Br J. Pharmacol. 39: 73 (1970).
E. S. Marks, M. French, D. Proud, and H. R. Keiser, Effect of alterations in extracellular fluid volume on urinary kallikrein in the conscious rat, Hypertension 4: 625 (1982).
G. Bönner, M. Marin-Grez, D. Beck, M. Delg, and F. Gross, Changes in renal and urinary kallikrein activity by mannitol-induced osmotic diuresis, Clin Sci. (Lond) 61: 47 (1981).
R. Geiger and K. Mann, A kallikrein-specific inhibitor in rat kidney tubules, Hoppe Seyler’s z. Physiol. Chem. 257: 553 (1976).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Plenum Press, New York
About this chapter
Cite this chapter
Yamada, K. et al. (1989). Interrelationship Between Urinary Kallikrein and Arginine-Vasopressin in Man. In: Abe, K., Moriya, H., Fujii, S. (eds) Kinins V. Advances in Experimental Medicine and Biology, vol 247 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9543-4_97
Download citation
DOI: https://doi.org/10.1007/978-1-4615-9543-4_97
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4615-9545-8
Online ISBN: 978-1-4615-9543-4
eBook Packages: Springer Book Archive