Abstract
Long before cytochrome P-450 was discovered, it was known that the metabolism of steroids was inhibited by CO (Ryan and Engel, 1957). It was a study of carbon monoxide inhibition of steroid metabolism by adrenal cortex which led to the discovery of the involvement of cytochrome P-450 in this reaction (Estabrook et al., 1963). Following this original observation, carbon monoxide inhibition of various monooxygenase reactions has been used in a number of laboratories to study the metabolism of these compounds. Philadelphia has been the site of a number of memorable experiments in the elucidation of the role of this enzyme in drug and steroid metabolism. Therefore, it is quite fitting that the subject of this paper be the control of cytochrome P-450 reactions and the role which carbon monoxide inhibition of cytochrome P-450 has played in obtaining an understanding of this control.
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© 1975 Plenum Press, New York
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Peterson, J.A., Mock, D.M. (1975). Metabolic Control of Cytochrome P-450cam . In: Cooper, D.Y., Rosenthal, O., Snyder, R., Witmer, C. (eds) Cytochromes P-450 and b5 . Advances in Experimental Medicine and Biology, vol 58. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-9026-2_21
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DOI: https://doi.org/10.1007/978-1-4615-9026-2_21
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