Abstract
The host response to infection with herpes simplex virus (HSV) in which both natural resistance and specific immunological responses become marshaled is clearly very complex. Natural resistance mechanisms, mediated for example by macrophages, NK cells, and interferon, represent a formidable early barrier to the virus (Lopez, Chapter 2, this volume), although the eventual resolution of the infectious process and the establishment of long-lasting antiviral defense is the property of the immune system. Whereas both humoral and cell-mediated responses are readily induced by the virus, it is clear that the action of T cells is central for recovery from the primary infection and in the control of recrudescent lesions. Much of this evidence comes from studies carried out in the mouse in which the precise nature of the T-cell response to herpes can readily be studied. In this respect the variety of inbred and congenic mouse strains has been invaluable in studying MHC restriction of T-cell responses; and the availability of monoclonal antibodies to specific T-cell subsets has enabled a detailed analysis of the antiviral T-cell response to be carried out.
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© 1985 Plenum Press, New York
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Nash, A.A., Leung, KN., Wildy, P. (1985). The T-Cell-Mediated Immune Response of Mice to Herpes Simplex Virus. In: Roizman, B., Lopez, C. (eds) The Herpesviruses. The Viruses. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-8021-8_4
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DOI: https://doi.org/10.1007/978-1-4615-8021-8_4
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