Abstract
Other contributors to this handbook already have clearly outlined the important role of the phosphoglycerides as components of membranes of the cells of the nervous system. This chapter is concerned with the manner in which the phosphoglycerides of the nervous system are formed and broken down. Only a brief discussion will be offered on the turnover and laying down of these lipids in the develo** brain, adult brain, and cells such as the Schwann cell or glial cell which are concerned with myelin formation and maintenance.
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References
G. B. Ansell and J. N. Hawthorne,in Phospholipids, Chemistry, Metabolism and Function, Biochim. Biophys. Acta Library Vol. 3 Elsevier, Amsterdam (1964).
R. M. C. Dawson,in Essays in Biochemistry (P. N. Campbell and G. D. Greville, eds.), Vol. 2, pp. 69–115, Academic Press, London and New York (1966).
K. P. Strickland,in Biogenesis of Natural Compounds (P. Bernfeld, ed.) 2nd ed., pp. 103–205, Pergamon Press, Oxford and New York (1967).
R. J. Rossiter,in Neurochemistry (K. A. C. Elliott, I. H. Page, and J. H. Quastel, eds.), 2nd ed., pp. 10–54, Charles C. Thomas, Springfield, Illinois (1962).
R. J. Rossiter,in Metabolism of the Nervous System (D. Richter, ed.), pp. 355–380, Pergamon Press, London and New York (1957).
R. J. Rossiter,in Neurochemistry (K. A. C. Elliott, I. H. Page, and J. H. Quastel, eds.), 2nd ed., pp. 870–896, Charles C. Thomas, Springfield, Illinois (1962).
E. P. Kennedy, Metabolism of lipides,Ann. Rev. Biochem. 26:119–148 (1957).
E. P. Kennedy, The metabolism and function of complex lipids,Harvey Lectures Ser. 57 143–171 (1961–1962).
R. J. Rossiter,in Metabolism and Physiological Significance of Lipids (R. M. C. Dawson and D. N. Rhodes, eds.), pp. 511–525, Wiley, London and New York (1964).
R. J. Rossiter,in Metabolic Pathways (D. M. Greenberg, ed.), 3rd ed. Vol. 2, pp. 70–115, Academic Press, New York (1968).
R. J. Rossiter and K. P. Strickland,in Lipide Metabolism (K. Bloch, ed.), pp. 69–127, Wiley, London and New York, (1960).
W. C. McMurray, K. P. Strickland, J. F. Berry, and R. J. Rossiter, Incorporation of32P-labelled intermediates into the phospholipids of cell-free preparations of brain,Biochem. J. 66:634–644 (1957).
W. P. Kennedy,Biosynthesis of Polyphosphoinositides in Brain, M.Sc. Thesis, University of Western Ontario, London, Canada (1968).
G. D. Greville,in Neurochemistry (K. A. C. Elliott, I. H. Page, and J. H. Quastel, eds.) 2nd ed., pp. 238–275, Charles C. Thomas, Springfield, Illinois (1962).
A. A. Abdel-Latif and L. G. Abood,In vivo incorporation of 1-[14C] serine into phospholipids and proteins of the subcellular fractions of develo** rat brain,J.Neurochem. 13:1189–1196 (1966).
G. B. Ansell and S. Spanner, The metabolism of labelled ethanolamine in the brain of the ratin vivo, J. Neurochem. 13:873–885 (1967).
G. B. Ansell and S. Spanner, The metabolism of14C-labelled choline and phosphoryl-choline in the brain of the ratin vivo, Biochem. J. 106:20P (1968).
K. Miyamoto, L. M. Stephanides, and J. Bernshohn, Incorporation of [1-14C] linoleate and linolenate into polyunsaturated fatty acids of phospholipids of the embryonic chick brain,J.Neurochem. 14:227–237 (1967).
A. F. D’Adamo, Jr., and A. P. D’Adamo, Acetyl transport mechanisms in the nervous system. The oxoglutarate shunt and fatty acid synthesis in the develo** rat brain, J. Neurochem. 15:315–323 (1968).
R. O. Brady, Biosynthesis of fatty acid II. Studies with enzymes obtained from brain,J. Biol. Chem. 235:3099–3103 (1960).
H. Debuch,in Metabolism and Physiological Significance of Lipids (R. M. C. Dawson and D. N. Rhodes, eds.), pp. 537–539, Wiley, London and New York (1964).
D. Gabal and K. Monty, The biosynthesis of plasmalogens,Federation Proc. 18:232(1959).
E. F. Hartree,in Metabolism and Physiological Significance of Lipids (R. M. C. Dawson and D. N. Rhodes, eds.), pp. 207–218, John Wiley, New York (1964).
A. Kornberg and W. E. Pricer, Jr., Enzymatic synthesis of phosphorus containing lipides,J. Am. Chem. Soc. 74:1617 (1952).
A. Kornberg and W. E. Pricer, Jr., Enzymatic esterification of α-glycerophosphate by long chain fatty acids,J. Biol. Chem. 204:345–357 (1953).
F. Possmayer and K. P. Strickland, The incorporation of a-glycerophosphate-32P into the lipids of rat brain preparations II. On the biosynthesis of monophospho-inositide.Can. J. Biochem. 45:63–70 (1967).
C. M. Redman and L. E. Hokin, Stimulation of the metabolism of phosphatidyl-inositol and phosphatidic acid in brain cytoplasmic fractions by low concentrations of cholinergic agents,J. Neurochem. 11:155–163 (1964).
P. M. Vignais, C. H. Gallagher, and I. Zabin, Activation and oxidation of long chain fatty acids by rat brain,J. Neurochem. 2:283–287 (1958).
R. A. Pieringer and L. E. Hokin, Biosynthesis of phosphatidic acid from lyso-phosphatidic acid and palmitoyl coenzyme A,J. Biol. Chem. 237:659–663 (1962).
W. E. M. Lands and P. Hart, Metabolism of glycerolipids: V. Metabolism of phosphatidic acid,J. Lipid Res. 5:81–87 (1964).
E. Martensson and J. Kanfer, The conversion of L-glycerol-14C 3-phosphate into phosphatidic acid by a solubilized preparation from rat brain,J. Biol. Chem. 243:497–501 (1968).
M. R. Hokin and L. E. Hokin, The synthesis of phosphatidic acid from diglyceride and adenosine triphosphate in extracts of brain microsomes,J. Biol. Chem. 234:1381–1386(1959).
K. P. Strickland, Phosphorylation of diglycerides by rat brain,Can. J. Biochem. Physiol. 40:247–259 (1962).
R. A. Pieringer and L. E. Hokin, Biosynthesis of lysophosphatidic acid from monoglyceride and adenosine triphosphate,J. Biol. Chem. 237:653–658 (1962).
J. F. Berry, C. F. McPherson, and R. J. Rossiter, Chemical studies of peripheral nerve during Wallerian degeneration—IX Choline Kinase,J. Neurochem. 3:65–71 (1958).
R. E. McCaman, Intermediary metabolism of phospholipids in brain tissue. Microdetermination of choline Phosphokinase,J. Biol. Chem. 237:672–676 (1962).
E. P. Kennedy and S. B. Weiss, The function of cytidine coenzymes in the biosynthesis of phospholipides,J. Biol. Chem. 222:193–214 (1956).
S. B. Weiss, S. W. Smith, and E. P. Kennedy, The enzymatic synthesis of lecithin from cytidine diphosphate choline and D-l,2-diglyceride,J. Biol. Chem. 231:53–64 (1968).
S. B. Weiss, E. P. Kennedy, and J. Y. Kiyasu, The enzymatic synthesis of triglycerides,J. Biol. Chem. 235:40–44 (1960).
R. J. Rossiter, I. M. McLeod, and K. P. Strickland, Biosynthesis of lecithin in brain and degenerating nerve. Participation of cytidine diphosphate choline,Can. J. Biochem. Physiol. 35:945–951 (1957).
K. P. Strickland, D. Subrahmanyam, E. T. Pritchard, W. Thompson, and R. J. Rossiter, Biosynthesis of lecithin in brain. Participation of cytidine diphosphate choline and phosphatidic acid,Biochem. J. 87:128–136 (1963).
R. E. McCaman and K. Cook, Intermediary metabolism of phospholipids in brain tissue. III. Phosphorylcholine—glyceride transferase,J. Biol. Chem. 241:3390–3394 (1966).
S. W. Smith, S. B. Weiss, and E. P. Kennedy, The enzymatic dephosphorylation of phosphatidic acids,J. Biol. Chem. 228:915–922 (1958).
R. J. Rossiter and K. P. Strickland, Biogenesis of phosphatides and triglycerides,Ann. N.Y. Acad. Sci. 72:790–802 (1959).
L. E. Hokin and M. R. Hokin, The presence of phosphatidic acid in animal tissues,J. Biol. Chem. 233:800–804 (1958).
R. Coleman and G. Hübscher, Metabolism of phospholipids V. Studies of phosphatidic acid phosphatase,Biochim. Biophys. Acta. 56:479–490 (1962).
R. E. McCaman, R. E. Smith, and K. Cook, Intermediary metabolism of phospholipids in brain tissue II. Phosphatidic acid phosphatase,J. Biol. Chem. 240:3513–3517 (1965).
W. E. M. Lands and I. Merkl, Metabolism of glycerolipids III. Reactivity of various acyl esters of coenzyme A with α1-acylglycerophosphorylcholine and positional specificities in lecithin synthesis,J. Biol. Chem. 238:898–904 (1963).
G. R. Webster, The incorporation of long-chain fatty acids into phospholipids of respiring slices of rat cerebrum,Biochem. J. 102:373–380 (1967).
G. B. Ansell and T. Chojnacki, Incorporation of 1-O-phosphoryl-2-dimenthyl-aminoethanol and phosphorylcholine into the phospholipids of brain and liver dispersions,Nature 196:545–547 (1962).
W. C. McMurray, Metabolism of phosphatides in develo** rat brain—I Incorporation of radioactive precursors.J. Neurochem. 11:287–299 (1964).
I. Merkl and W. E. M. Lands, Metabolism of glycerolipids. IV. Synthesis of phosphatidylethanolamine,J. Biol. Chem. 238:905–906 (1963).
L. F. Borkenhagen, E. P. Kennedy, and L. Fielding, Enzymatic formation and decarboxylation of phosphatidylserine,J. Biol. Chem. 236:PC28–30 (1961).
G. Hübscher, Metabolism of phospholipids VI. The effect of metal ions on the incorporation of L-serine into phosphatidylserine,Biochim. Biophys. Acta. 57:555–561 (1962).
E. T. Pritchard, the formation of glycerophosphatides from C14-labelled precursors in rat brain slices,Can. J. Biochem. Physiol. 36:1211–1220 (1958).
J. Y. Kiyasu and E. P. Kennedy, The enzymatic synthesis of plasmalogens,J. Biol. Chem. 235:2590–2594 (1960).
W. C. McMurray, Metabolism of phosphatides in develo** rat brain—II. Labelling of plasmalogens and other alkali-stable lipids from radioactive cytosine nucleotides,J. Neurochem. 11:315–326 (1964).
G. B. Ansell and R. F. Metcalfe, The labelling of brain phospholipids by cytidine 5′-diphosphate ethanolaminein vitro, Biochem. J. 98:22P (1966).
K. Waku and W. E. M. Lands, Acyl coenzyme A: 1-Alkenyl-glycero-3-phosphoryl-choline acyltransferase action in plasmalogen biosynthesis,J. Biol. Chem. 243:2654–2659 (1968).
G. A. Thompson, Jr., The biosynthesis of ether-containing phospholipids in the slug,Arion ater. II. The role of glyceryl ether lipids as plasmalogen precursors,Biochemistry 5:1290–1296 (1966).
G. A. Thompson, Jr., The biosynthesis of ether-containing phospholipids in the slug,Arion ater. III. Origin of the vinylic ether bond of plasmalogens,Biochim. Biophys. Acta. 152:409–411 (1968).
L. A. Horrocks and G. B. Ansell, The incorporation of ethanolamine into ether-containing lipids in rat brain,Lipids 2:329–333 (1967).
R. Bickerstaffe and J. F. Mead, Metabolism of palmitaldehyde-1-14C in the rat brain,Biochemistry 6:655–662 (1967).
E. O. Oswald, C. E. Anderson, C. Piantadosi, and J. Lim, Metabolism of alkyl glyceryl ethers in the rat,Lipids 3:51–58 (1968).
B. W. Agranoff, R. M. Bradley, and R. O. Brady, The enzymatic synthesis of inositol phosphatide,J. Biol. Chem. 233:1077–1083 (1958).
W. Thompson, K. P. Strickland, and R. J. Rossiter, Biosynthesis of phosphatidyl-inositol in rat brain,Biochem. J. 87:136–142 (1963).
H. Paulus and E. P. Kennedy, The enzymatic synthesis of inositol monophosphatide,J. Biol. Chem. 235:1303–1311 (1960).
G. L. Petzold and B. W. Agranoff, The biosynthesis of cytidine diphosphate diglyceride by embryonic chick brain,J. Biol. Chem. 242:1187–1191 (1967).
M. A. Wells and J. C. Dittmer, The identification of glycerophosphorylglycerol phosphate as the deacylation product of a new brain lipid,J. Biol. Chem. 241:2103–2105 (1966).
J. Y. Kiyasu, R. A. Pieringer, H. Paulus, and E. P. Kennedy, The biosynthesis of phosphatidyl glycerol,J. Biol. Chem. 238:2293–2298 (1963).
J. Lecocq and C. E. Ballou, On the structure of cardiolipin,Biochemistry 3:979–980 (1964).
F. Possmayer, G. Balakrishnan, and K. P. Strickland, The incorporation of labelled α-glycerophosphate into the lipids of rat brain preparations. III. On the biosynthesis of phosphatidyl glycerol,Biochim. Biophys. Acta, in press.
L. L. M. Van Deenen,in Metabolism and Physiological Significance of Lipids (R. M. C. Dawson and D. N. Rhodes, eds.), pp. 155–178, Wiley, London and New York (1964).
L. L. M. Van Deenen and G. H. Haas, Phosphoglycerides and phospholipases,Ann. Rev. Biochem. 35:157–194 (1966).
R. H. S. Thompson,in Metabolism and Physiological Significance of Lipids (R. M. C. Dawson and D. N. Rhodes, eds.), pp. 541–551, Wiley, London and New York (1964).
G. R. Webster, Some aspects of lipid metabolism in nervous tissue,Intern. Rev. Neurobiol. 3:293–317 (1961).
J. Gallai-Hatchard, W. L. Magee, R. H. S. Thompson, and G. R. Webster, The formation of lysophosphatides from di-acyl phosphatides by brain preparations,J. Neurochem. 9:545–554 (1962).
S. Gatt, Y. Barenholz, and A. Roitman, Isolation of rat brain lecithinase-A, specific for the apposition of lecithin,Biochem. Biophys. Res. Commun. 24:169–172 (1966).
S. Gatt, Purification and properties of phospholipase A1 from rat and calf brain,Biochim. Biophys. Acta 159:304–316 (1968).
A. F. Robertson and W. E. M. Lands, Positional specificities in phospholipid hydrolyses,Biochemistry 1:804–810 (1962).
E. A. Marples and R. H. S. Thompson, The distribution of phospholipase B in mammalian tissues,Biochem. J. 74:123–127 (1960).
G. R. Webster, E. A. Marples, and R. H. S. Thompson, Glycerylphosphorylcholine diesterase activity of nervous tissue,Biochem. J. 65:374–377 (1957).
K. P. Strickland, R. H. S. Thompson, and G. R. Webster, The Action of the phosphatases of human brain on lipid phosphate esters,J. Neurol. Neurosurg. Psychiat. 19:12–16 (1956).
K. P. Strickland, R. H. S. Thompson, and G. R. Webster, Hydrolysis of phosphoryl choline and related esters by the phosphomonoesterases of animal tissues,Arch. Biochem. Biophys. 64:498–505 (1956).
G. B. Ansell and S. Spanner, The catabolism of ethanolamine-containing phospholipids in rat-brain preparations,Biochem. J. 98:23P (1966).
G. B. Ansell and S. Spanner, Plasmalogenase activity in normal and demyelinating tissue of the central nervous system,Biochem. J. 108:207–209 (1968).
A. N. Davison,in Metabolism and Physiological Significance of Lipids (R. M. C. Dawson and D. N. Rhodes, eds.), pp. 527–537, Wiley, London and New York (1964).
M. L. Cuzner, A. N. Davison, and N. A. Gregson, Turnover of brain mitochondrial lipids,Biochem. J. 101:618–626 (1966).
M. L. Cuzner, A. N. Davison, and N. A. Gregson, Chemical and metabolic studies of rat myelin of the central nervous system,Ann. N. Y. Acad. Sci. 122:86–94 (1965).
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© 1970 Plenum Press, New York
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Rossiter, R.J., Strickland, K.P. (1970). Metabolism of Phosphoglycerides. In: Lajtha, A. (eds) Metabolic Reactions in the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-7160-5_16
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DOI: https://doi.org/10.1007/978-1-4615-7160-5_16
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