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Characteristics and Mechanisms of Angiotensin II-Related Myocardial Damage

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Angiotensin II Receptor Blockade Physiological and Clinical Implications

Part of the book series: Progress in Experimental Cardiology ((PREC,volume 2))

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Summary

Chronic, pathophysiological elevations of angiotensin (Ang) II cause myocyte necrosis and coronary vascular damage. These adverse effects are mediated by the angiotensin II type 1 (AT1) receptor and are, therefore, preventable with AT1 receptor blockade. Additionally, the intracellular signaling cascade stimulated by elevations in Ang II results in an AT1 receptor-mediated catecholamine release, and the myocardial damage can also be attenuated by β1-adrenergic receptor blockade. The restriction of myocardial damage to the first 3 days of Ang II infusion is due to subsequent downregulation of the β1-adrenergic receptor population. Discontinuation of the Ang II infusion results in a return to normal β1-adrenergic receptor density, which makes the myocardium susceptible once again to subsequent elevations of Ang II. This Ang II-related myocardial damage could play an important role in the pathogenesis of heart failure post-myocardial infarction or in other cardiac disease states.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology, Auburn University, Auburn, Alabama, USA

    Jeffrey R. Henegar, Gregory L. Brower & Joseph S. Janicki

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  1. Jeffrey R. Henegar
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  2. Gregory L. Brower
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  3. Joseph S. Janicki
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Editor information

Editors and Affiliations

  1. Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre Faculty of Medicine, University of Manitoba, Winnipeg, Canada

    Naranjan S. Dhalla Ph.D., M.D. (Hon.) (Distinguished Professor and Director MRC Group in Experimental Cardiology), Peter Zahradka Ph.D. (Associate Professor), Ian M. C. Dixon Ph.D. (Assistant Professor) & Robert E. Beamish M.D. (Professor Emeritus) (Distinguished Professor and Director MRC Group in Experimental Cardiology),  (Associate Professor),  (Assistant Professor) &  (Professor Emeritus)

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© 1998 Springer Science+Business Media New York

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Henegar, J.R., Brower, G.L., Janicki, J.S. (1998). Characteristics and Mechanisms of Angiotensin II-Related Myocardial Damage. In: Dhalla, N.S., Zahradka, P., Dixon, I.M.C., Beamish, R.E. (eds) Angiotensin II Receptor Blockade Physiological and Clinical Implications. Progress in Experimental Cardiology, vol 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5743-2_37

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  • DOI: https://doi.org/10.1007/978-1-4615-5743-2_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-7631-6

  • Online ISBN: 978-1-4615-5743-2

  • eBook Packages: Springer Book Archive

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