Abstract
Inflammation has been aptly described as a wound that does not heal. The definition recognizes that the factors that contribute to the normal repair process also control the disease process of inflammation. Cytokines are the protein signals used by the cells in the immune system. The cytokines include at least 18 interleukins, the tumor necrosis factors, the interferons, colony-stimulating factors, chemokines, and a variety of growth factors including transforming growth factor β and the family of fibroblast growth factors. Differentiating normal control of cytokine function from the dysregulation that characterizes inflammation is a challenge. This review will consider a few basic principles of cytokine function, describe the research to date that specifically relates cytokines to dry eyes, and then consider how genetically altered animals may help resolve some of the paradoxes relating to an understanding of cytokines.
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Rosenbaum, J.T., Brito, B., Han, Y.B., Park, J., Planck, S.R. (1998). Cytokines. In: Sullivan, D.A., Dartt, D.A., Meneray, M.A. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2. Advances in Experimental Medicine and Biology, vol 438. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5359-5_61
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DOI: https://doi.org/10.1007/978-1-4615-5359-5_61
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