Abstract
The BB rat is an animal model of type 1 insulin dependent diabetes mellitus which is thought to have emerged after a spontaneous mutation in a non-inbred colony of Wistar rats at the Biobreeding laboratories in Ottawa in 1974.(ref 1 and 2) As a result of this a colony of diabetes prone (BBDP) animals was established and rats were sent around the world where similar colonies were founded. Some laboratories (in Worcester and Edinburgh for example) have established diabetes resistant sublines (BBDR) with a 0% incidence out of the same stock and maintained them alongside the BBDP colony to serve as a source of related unaffected control animals.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Chappel C.I and Chappel W.R, 1983. The discovery and development of the BB rat colony: an animal model of spontaneous diabetes mellitus. Metabolism 32 (suppl 1) p 8–10.
Nakhooda A F, Like A A, Chappel C I, Murray F T, and Marliss E B, 1977. The spontaneously diabetic Wistar rat: metabolic and morphologic studies. Diabetes 26:100–112.
Walker R, Bone A J, Cooke A and Baird J D, 1988. Distinct macrophage subpopulations in the pancreas of prediabetic BB/E rats: possible role for macrophages in the pathogenesis of IDDM. Diabetes 37:1301–1304.
Cooke A,1990. An overview on possible mechanisms of destruction of the insulin-producing beta cell. Current topics in microbiology and immunology 164:125–137.
Metroz Dayer M D, Mouland M, Brideau C, Duhamel D and Poussier P, 1990. Adoptive transfer of diabetes in BB rats induced by CD4+ lymphocytes. Diabetes 39:928–932.
Like A A, Kislauskis E, Williams R M and Rossini A A, 1982. Neonatal thymectomy prevents spontaneous diabetes mellitus in the BBIW rat. Science 216:644–646.
Bone A J, Walker R, Varey A M, Cooke A and Baird J D, 1990. Effect of cyclosporin on pancreatic events and development of diabetes in BB/Edinburgh rats. Diabetes 39:508–513.
Jackson R, Rassi N, Crump T, Haynes B and Eisenbarth G S, 1981,. The BB diabetic rat. Profound T cell lymphocytopenia. Diabetes 30:887–889.
Bellgrau D, Nagi A, Silvers W K, Markmann J F and Barker C F, 1982, Spontaneous diabetes in BB rats: evidence for a T cell dependent immune response defect. Diabetologia 23:359–364.
Elder M and Maclaren N K,1983, Identification of profound T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat. J.lmmunol. 130:1723–1730.
Woda B A, Like A, Padden C and McFadden M, 1986, Deficiency of phenotypic cytotoxic suppressor T lymphocytes in the spontaneously diabetic BB rat. J I vol 136 p 856–859.
Greiner D, Handler E S, Nakano K, Mordes J P and Rossini A A, 1986, Absence of the RT6 T cell subset in diabetes prone BB/W rats. J.lmmunol. 136:148–151.
Thiele H G, Koch F Hammanand and Arndt R 1986. Biochemical characterisation of the T cell alloantigen RT6.2. Immunology 59:195–202
Greiner D L, Mordes J P, Handler E S, Angellino M, Nakamura N and Rossini A A, 1987. Depletion of RT6.1+ T lymphocytes in diabetes resistant BioBreeding (BB/W) rats. J. Exp.Med 166:461–475.
Cormier J N, Handler E S, Mordes J P and Rossini A A, 1989. silica fails to prevent diabetes in RT6 depleted resistant (DR) BB rats or adoptive transfer of diabetes in diabetes prone (DP) BB rats. Clin. Res. 37 no.3 (meeting abstract)
Colle E, Guttman R.D, Seemayer T.A 1981, Spontaneous diabetes mellitus syndrome in the rat. 1. Association with the major histocompatibilty complex of the rat. J.Exp.Med. 154:1237–1242.
Jackson R, Buse J B, Rifai R, Pelletier D, Milforde L, Carpenter C B, Eisenbarth G S and Williams M, 1984, Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses. J.Exp.Med 159:1629–1636.
Kloeting I and Stark O, 1987, Genetic studies of IDDM in BB rats: the incidence of diabetes in F2 and first backcross hybrids allows rejection of the recessive hypothesis. Exp. Clin. Endocrinol. 89:312–318.
Gunther E, Kiesel M, Kolb H, Krawczak M, Rothermel E and Wurst W, 1991, Genetic analysis of susceptibility to diabetes mellitus in F2 hybrids between DPBB and various MHC recombinant congenic rat strains. J. Autoimmunity 4:543–551.
Markholst H, Eastman S, Wilson D, Adreason B. E, and Lernmark A, 1991, Diabetes segregates as a single locus in crosses between inbred BB rats, prone or resistant to diabetes. J.Exp.Med. 174:297–300.
Colle E, Guttmann R D and Fuks A, 1986, Insulin dependent diabetes mellitus is associated with genes that map to the right of the class I RTI.A locus of the major histocompatibility complex of the rat. Diabetes 35:454–458
Colle E, Guttman R D, Fuks A, Seemayer T A and Prud’homme G J, 1986, Genetics of the spontaneous genetic syndrome. Interaction of MHC and non-MHC associated factors. Mol. Biol. Med 3:13–23.
Guttmann R D, Colle E, Michel F and Seemayer T, 1983, Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration. J.Immunol. 130:1732–1735.
Butcher G W, 1987, A list of monoclonal antibodies specific for alloantigens of the rat. J. Immunogenetics 14:163–176.
Davidson W F and Parish C R, 1975, A procedure for removing red cells and dead cells from lymphoid cell suspensions. J.Immunol. Methods 7:291–300.
Brideau R J, Carter P B, McMaster W R, Mason D W and Williams A F, 1980, Two subsets of rat lymphocytes defined with monoclonal antibodies. Eur. J. Immunol. 10:609–615.
Dallman M J, Mason D W and Webb M, 1982. The roles of host and donor cells in the rejection of skin allografts by T cell depleted rats injected with syngeneic T cells. E.J.I 12;511–518
Jeffries W A, Green J R and Williams A F, 1985, Authentic T helper CD4 (W3/25) antigen on rat peritoneal macrophages. J. Exp. Med 162:117–127.
Hunig T, Wallney H J, Hartley J K, Lawetzky A and Tiefenthaler G, 1989, A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes. J. Exp. Med 169:73–86.
Springer T A, Bhattacharya A, Cardoza J T and Sanchez-Madrid F, 1982, Monoclonal antibodies specific for rat IgG1 and IgG2a and IgG2b subclasses and kappa chain monotypic and allotypic determinants: reagents for use with rat monoclonal antibodies. Hybridoma 1:257–273.
Malache J M, Manouvriez P and Bazin H, 1990, List of monoclonal antibodies. Chapter in: Rat hybridomas and monoclonal antibodies. (Ed) H. Bazin. CRC Press, Boca Raton, Florida.
Robinson A P, White T M and Mason D W, 1986. MRCOX43: a monoclonal antibody which reacts with all vascular endothelium in the rat except that of brain capillaries. Immunology 57:231–237.
Williams A, Galfre G and Milstein C, 1977. Analysis of cell surfaces by xenegeneic myeloma hybrid antibodies: Differentiation of rat lymphocytes. Cell 12:663–673
Chambers W H, Vujanovic N L, Deleo A B, Olszowy M W, Herberman R B and Hiserodt J C, 1989. Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine activated killer cells. J.Exp. Med. 169:1373–1389
Like A A, Biron C A, Weringer E S, Brayman K, Sroczynski E and Guberski D L, 1986. Prevention of diabetesin BioBreeding Worcester rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells. J.Exp. Med 164:1145–1159.
Rothe H, Fehsel K and Kolb H, 1989. Aberrant production of TNFα by macrophages from diabetes prone BB rats. Abstract (p 26) in Lessons from animal diabetes,3rd international workshop in Israel.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer Science+Business Media New York
About this chapter
Cite this chapter
Joseph, S., Butcher, G., Smith, W., Baird, J. (1992). The Relationship between Diabetes and Lymphopenia in the BB Rat. In: Celada, F., Pernis, B. (eds) T Lymphocytes. NATO ASI Series, vol 233. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-3054-1_16
Download citation
DOI: https://doi.org/10.1007/978-1-4615-3054-1_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6332-3
Online ISBN: 978-1-4615-3054-1
eBook Packages: Springer Book Archive