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Inherited Susceptibility to CLL

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Advances in Chronic Lymphocytic Leukemia

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 792))

Abstract

Chronic lymphocytic leukaemia (CLL) is the most common lymphoid malignancy in Western countries, accounting for around a quarter of all leukaemias. Despite a strong familial basis to CLL, with risks in first-degree relatives of CLL cases being increased around sevenfold, the inherited genetic basis of CLL is currently largely unknown. The failure of genetic studies of CLL families to provide support for a major disease-causing locus has suggested a model of susceptibility based on the co-inheritance of multiple low-risk variants, some of which will be common. Recent genome-wide association studies of CLL have vindicated this model of inherited susceptibility to CLL, identifying common variants at multiple independent loci influencing risk. Here we review the evidence for inherited genetic predisposition to CLL and what the currently identified risk loci are telling us about the biology of CLL development.

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Acknowledgements

Work in the author’s laboratory is supported by the Leukaemia Lymphoma Research, Cancer Research UK and the Arbib Foundation. GS is in receipt of a PhD studentship from the Institute of Cancer Research.

Conflict of interest: The authors declare that there are no conflicts of interest.

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  1. Division of Genetics and Epidemiology, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK

    Helen E. Speedy, Georgina Sava & Richard S. Houlston

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  1. Helen E. Speedy
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  2. Georgina Sava
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  3. Richard S. Houlston
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Correspondence to Richard S. Houlston .

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  1. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA

    Sami Malek

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Speedy, H.E., Sava, G., Houlston, R.S. (2013). Inherited Susceptibility to CLL. In: Malek, S. (eds) Advances in Chronic Lymphocytic Leukemia. Advances in Experimental Medicine and Biology, vol 792. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8051-8_13

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