Synergistic Effects of Taurine and l-Arginine on Attenuating Insulin Resistance Hypertension

Abstract

To elucidate the synergistic effects of taurine and l-arginine on hypertension, 25% fructose were administered to male Wistar rats for 3 months to establish insulin resistance hypertensive models. Rats with the systolic blood pressure (SBP) higher than 150 mmHg were considered as model rats. Forty-two model rats were randomly divided into six groups and administered with 3% taurine, 2.7% taurine + 0.3% l-arginine, 2.1% taurine + 0.9% l-arginine, 1.5% taurine + 1.5% l-arginine and 3% l-arginine in drinking water respectively. The results showed that coadministration of taurine (1.5%) and l-arginine (1.5%) could bring the levels of SBP, blood glucose, and insulin down to normal levels after 4 weeks. The thickness of blood vessels increased significantly in model group, which could be reversed by taurine and l-arginine. Serum NO, cGMP, and ET levels could return to normal levels. These data indicated that both taurine and l-arginine could ameliorate vascular remodeling and showed obvious antihypertensive effects, and taurine (1.5%) and l-arginine (1.5%) in the drinking water showed a better result in the cure of hypertension.