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Radiotherapy Aspects of Malignant Diseases of the Oral Cavity

  • Chapter
Oral Oncology

Part of the book series: Developments in Oncology ((DION,volume 20))

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Abstract

The oral cavity forms the most proximal portion of the alimentary tract and serves as part of the upper airway. It provides the portal of entry to the body for food and fluids and serves as the initial site of digestive function through the mechanisms of mastication and salivation. The structures within the mouth, including the palate, tongue, and buccal regions, are an integral part of the speech apparatus. The oral mucosa is a protective barrier and collects sensory information relating to touch, pain, temperature, and taste. Efforts to treat tumors arising in the oral cavity must be directed not only at preserving the life of the patient, but also at preserving these functions as completely as possible.

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References

  1. Lederman M. Cancer of the oral cavity: Observations on classification and natural history. Int J Radiat Oncol Biol Phys (6): 1559–1565, 1980.

    PubMed  CAS  Google Scholar 

  2. Gilbert H, Kagan AR. Recurrence patterns in squamous cell carcinoma of the oral cavity, pharynx, and larynx. J Surg Oncol (6): 357–380, 1974.

    PubMed  CAS  Google Scholar 

  3. Frazell EL. A review of the treatment of cancer of the mobile portion of the tongue. Cancer (28): 1178–1181, 1971.

    PubMed  CAS  Google Scholar 

  4. Fletcher GH. Place of irradiation in the management of head and neck cancers. Semin Oncol (4): 375–385, 1977.

    PubMed  CAS  Google Scholar 

  5. Fitzpatrick PJ, Tepperman BS. Carcinoma of the floor of the mouth. J. Can Assoc Radiol (33): 148–153, 1982.

    PubMed  CAS  Google Scholar 

  6. Hintz B, Charyulu K, Chandler JR, Sudarsanam A, Garciga C. Randomized study of local control and survival following radical surgery or radiation therapy in oral and laryngeal carcinomas. J Surg Oncol (12): 61–74, 1979.

    PubMed  CAS  Google Scholar 

  7. Ange DW, Lindberg RD, Guillamondegui OM. Management of squamous cell carcinoma of the oral tongue and floor of mouth after excisional biopsy. Radiology (116): 143–146, 1975.

    PubMed  CAS  Google Scholar 

  8. Fu KK, Chan EK, Phillips TL, Ray JW. Time, dose and volume factors in interstitial radium implants of carcinoma of the oral tongue. Radiology (119): 209–213, 1976.

    PubMed  CAS  Google Scholar 

  9. Chu A, Fletcher GH. Incidence and causes of failures to control by irradiation the primary lesions in squamous cell carcinomas of the anterior two-thirds of the tongue and floor of mouth. AJR (117): 502–508, 1973.

    CAS  Google Scholar 

  10. Lees AW. The treatment of carcinoma of the anterior two-thirds of the tongue by radiotherapy. Int J Radiat Oncol Biol Phys (1): 849–858, 1976.

    PubMed  CAS  Google Scholar 

  11. Mendenhall WM, Million RR, Cassisi NJ. Elective neck irradiation in squamous-cell carcinoma of the head and neck. Head Neck Surg (3): 15–20, 1980.

    PubMed  CAS  Google Scholar 

  12. Gilbert EH, Goffinet DR, Bagshaw MA. Carcinoma of the oral tongue and floor of mouth: Fifteen years’ experience with linear accelerator therapy. Cancer (35): 1517–1524, 1975.

    PubMed  CAS  Google Scholar 

  13. Pierquin B, Chassagne D, Baillet F, Castro JR. The place of implantation in tongue and floor of mouth cancer. JAMA (215): 961–963, 1971.

    PubMed  CAS  Google Scholar 

  14. Bedwinek JM, Shukovsky LJ, Fletcher GH, Daley TE. Osteonecrosis in patients treated with definitive radiotherapy for squamous cell carcinomas of the oral cavity and naso- and oropharynx. Radiology (119): 665–667, 1976.

    PubMed  CAS  Google Scholar 

  15. Fayos JV. The role of radium implants in cancer of the oral cavity and oral pharynx. Int J Radiat Oncol Biol Phys (6): 423–429, 1980.

    PubMed  CAS  Google Scholar 

  16. Fletcher GH. Textbook of Radiotherapy, 3rd ed. Philadelphia: Lea and Febiger, 1980.

    Google Scholar 

  17. Sahatchiev A, Moushmov M, Kirov S. Results of radical treatment of cancer of the anterior two-thirds of the tongue. Cancer (30): 703–707, 1972.

    PubMed  CAS  Google Scholar 

  18. Richaud P, Tapley ND: Lateralized lesions of the oral cavity and oropharynx treated in part with the electron beam. Int J Radiat Oncol Biol Phys (5): 461–465, 1979.

    PubMed  CAS  Google Scholar 

  19. Barker JL, Fletcher GH. Time, dose and tumor volume relationships in megavoltage irradiation of squamous cell carcinomas of the retromolar trigone and anterior tonsillar pillar. Int J Radiat Oncol Biol Phys (2): 407–414, 1977.

    PubMed  CAS  Google Scholar 

  20. Chung CK, Rahman SM, Lim ML, Constable WC. Squamous cell carcinoma of the hard palate. Int J Radiat Oncol Biol Phys (5): 191–196, 1979.

    PubMed  CAS  Google Scholar 

  21. Farr HW, Arthur K. Epidermoid carcinoma of the mouth and pharynx, 1960–1964. Elective radical neck dissection. Clin Bull (1): 130–135, 1971.

    Google Scholar 

  22. Cachin Y, Eschwege F. Combination of radiotherapy and surgery in the treatment of head and neck cancers. Cancer Treat Rev (2): 177–191, 1975.

    PubMed  CAS  Google Scholar 

  23. Ketcham AS, Hoye RC, Chretien PB, Brace KC. Irradiation twenty-four hours preopera-tively. Am J Surg (118): 691–697, 1969.

    PubMed  CAS  Google Scholar 

  24. Lawrence WJr, Terz JJ, Rogers C, King RE, Wolf JS, King ER. Preoperative irradiation for head and neck cancer: A prospective study. Cancer (33): 318–323, 1974.

    PubMed  Google Scholar 

  25. Kramer S. Comparison of preoperative and postoperative radiation therapy for patients with carcinoma of the head and neck—The RTOG Study. Presented at Am Soc Ther Radiol, 1980.

    Google Scholar 

  26. Hamberger AD, Fletcher GH, Guillamondegui OM, Byers RM. Advanced squamous cell carcinoma of the oral cavity and oropharynx treated with irradiation and surgery. Radiology (119): 433–438, 1976.

    PubMed  CAS  Google Scholar 

  27. Marcus RB, Million RR, Cassisi NJ. Postoperative irradiation for squamous cell carcinomas of the head and neck: Analysis of time-dose factors related to control above the clavicles. Int J Radiat Oncol Biol Phys (5): 1943–1949, 1979.

    PubMed  Google Scholar 

  28. Vikram B. Importance of the time interval between surgery and postoperative radiation therapy in the combined management of head and neck cancer. Int J Radiat Oncol Biol Phys (5): 1837–1840, 1979.

    PubMed  CAS  Google Scholar 

  29. Looser KG, Shah JP, Strong EW. The significance of “positive” margins in surgically resected epidermoid carcinomas. Head Neck Surg (1): 107–111, 1978.

    PubMed  CAS  Google Scholar 

  30. Fletcher GH, Evers WT. Radiotherapeutic management of surgical recurrences and postoperative residuals in tumors of the head and neck. Radiology (95): 185–188, 1970.

    PubMed  CAS  Google Scholar 

  31. Kraus FT, Perez-Mesa C. Verrucous carcinoma. Cancer (19): 26–38, 1966.

    PubMed  CAS  Google Scholar 

  32. Memula N, Ridenhour G, Doss LL. Radiotherapeutic management of oral cavity verrucous carcinoma. Proc. 22nd Annual Meeting Amer Soc Ther Radiol, Int J Radiat Oncol Biol Phys (6): 1404, 1980.

    Google Scholar 

  33. Burns HP, Van Nostrand AWP, Palmer JA. Verrucous carcinoma of the oral cavity: Management by radiotherapy and surgery. Can J Surg (23): 19–25, 1980.

    PubMed  CAS  Google Scholar 

  34. Fayos JV. Carcinoma of the mandible. Result of radiation therapy. Acta Radiol (Ther) (12): 378–386, 1973.

    CAS  Google Scholar 

  35. Porter EH. The local prognosis after radical radiotherapy for squamous carcinoma of the alveolus or the floor of the mouth. Clin Radiol (22): 139–143, 1971.

    PubMed  CAS  Google Scholar 

  36. Henk JM. Radiosensitivity of lymph node metastases. Proc R Soc Med (68): 85–86, 1975.

    PubMed  CAS  Google Scholar 

  37. del Regato JA, Spjut HJ. Ackerman and del Regato’s Cancer Diagnosis, Treatment, and Prognosis, 5th Ed. St. Louis: C.V. Mosby, 1977.

    Google Scholar 

  38. Lindberg R. Distribution of cervical lymph node metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer (29): 1446–1449, 1972.

    PubMed  CAS  Google Scholar 

  39. Mendenhall WM, Million RR, Cassisi NJ. Elective neck irradiation in squamous cell carcinoma of the head and neck. Head Neck Surg (3): 15–20, 1980.

    PubMed  CAS  Google Scholar 

  40. Beahrs OH, Barber KW Jr. The value of radical dissection of structures of the neck in the management of carcinoma of the lip, mouth, and larynx. Arch Surg (85): 49–56, 1962.

    PubMed  CAS  Google Scholar 

  41. Lyall D, Shetlin CF. Cancer of the tongue. Ann Surg (135): 489–496, 1952.

    PubMed  CAS  Google Scholar 

  42. Sako K, Pradier RN, Marchetta FC, Pickren JW. Fallibility of palpation in the diagnosis of metastases to cervical nodes. Surg Gynecol Obstet (118): 989–990, 1964,

    PubMed  Google Scholar 

  43. Vandenbrouck C, Sancho-Garnier H, Chassagne D, Saravane D, Cachin Y, Micheau C. Elective versus therapeutic radical neck dissection in epidermoid carcinoma of the oral cavity. Cancer (46): 386–390, 1980.

    PubMed  CAS  Google Scholar 

  44. Pointon, RC. Personal communication.

    Google Scholar 

  45. Jesse RH, Barkley HT Jr, Lindberg RD, Fletcher GH. Cancer of the oral cavity. Is elective neck dissection beneficial? Am J Surg (120): 505–508, 1970.

    PubMed  CAS  Google Scholar 

  46. Northrop M, Fletcher GH, Jesse RH, Lindberg RD. Evolution of neck disease in patients with primary squamous cell carcinoma of the oral tongue, floor of mouth, and palatine arch, and clinically positive neck nodes neither fixed nor bilateral. Cancer (29): 23–30, 1972.

    PubMed  CAS  Google Scholar 

  47. Nahum AM, Bone RC, Davidson TM. The case for elective prophylactic neck dissection. Trans Am Acad Ophtholmol Otolaryngol (82): 603–612, 1976.

    CAS  Google Scholar 

  48. Fletcher GH. Elective irradiation of subclinical disease in cancers of the head and neck. Cancer (29): 1450–1454, 1972.

    PubMed  CAS  Google Scholar 

  49. Bagshaw MA, Thompson RW. Elective irradiation of the neck in patients with primary carcinoma of the head and neck. JAMA (217): 456–458, 1971.

    PubMed  CAS  Google Scholar 

  50. Million RR. Elective neck irradiation for TxNo squamous carcinoma of the oral tongue and floor of mouth. Cancer (34): 149–155, 1974.

    PubMed  CAS  Google Scholar 

  51. Horiuchi J, Adachi T. Some considerations on radiation therapy of tongue cancer. Cancer (28): 335–339, 1971.

    PubMed  CAS  Google Scholar 

  52. Goffinet DR, Gilbert EH, Weller SA, Bagshaw MA. Irradiation of clinically uninvolved cervical lymph nodes. Can J Otolaryngol (4): 927–933, 1975.

    PubMed  CAS  Google Scholar 

  53. Toker C. Some observations on the distribution of metastatic squamous carcinoma within cervical lymph nodes. Ann Surg (157): 419–426, 1963.

    PubMed  CAS  Google Scholar 

  54. Wizenberg MJ, Bloedorn FG, Weiner S, Gracia J. Treatment of lymph node metastases in head and neck cancer. A radiotherapeutic approach. Cancer (29): 1455–1462, 1972.

    CAS  Google Scholar 

  55. Hanks GE, Bagshaw MA, Kaplan HS. The management of cervical lymph node metastasis by megavoltage radiotherapy. AJR (105): 74–82, 1969.

    CAS  Google Scholar 

  56. Merino OR, Lindberg RD, Fletcher GH. An analysis of distant metastases from squamous cell carcinoma of the upper respiratory and digestive tracts. Cancer (40): 145–151, 1977.

    PubMed  CAS  Google Scholar 

  57. Strong EW. Preoperative radiation and radical neck dissection. Surg Clin North Am (49): 271–276, 1969.

    PubMed  CAS  Google Scholar 

  58. Schneider JJ, Fletcher GH, Barkley HT Jr. Control by irradiation alone of nonfixed clinically positive lymph nodes from squamous cell carcinoma of the oral cavity, oropharynx, supraglottic larynx, and hypopharynx. AJR (123): 42–48, 1975.

    CAS  Google Scholar 

  59. Bataini JP, Brugere J, Ghossein NA, Bernier J, Jaulerry C, Brunin F. Radiotherapeutic control of subclinical and clinical neck disease in patients with cancers of supraglottic larynx and pharynx. Proc. International Head and Neck Oncology Research Conference, Rosslyn, Virginia, Sept. 8–10, 1980. Abstract 1.2.

    Google Scholar 

  60. Cachin Y, Sancho-Garnier H, Micheau C, Marandas P. Nodal metastasis from carcinomas of the oropharynx. Otolaryngol Clin North Am (12): 145–154, 1979.

    PubMed  CAS  Google Scholar 

  61. Goodwin WJ Jr, Chandler JR. Indications for radical neck dissection following radiation therapy. Arch Otolaryngol (104): 367–370, 1978.

    PubMed  Google Scholar 

  62. Barkley HT Jr, Fletcher GH, Jesse RH, Lindberg RD. Management of cervical lymph node metastases in squamous cell carcinoma of the tonsillar fossa, base of tongue, supraglottic larynx, and hypopharynx. Am J Surg (124): 462–467, 1972.

    PubMed  Google Scholar 

  63. Garofalo JA, Erlandson E, Strong EW, Lesser M, Gerold F, Spiro R, Schwartz M, Good RA. Serum zinc, serum copper, and the Cu/Zn ratio in patients with epidermoid cancers of the head and neck. J Surg Oncol (15): 381–386, 1980.

    PubMed  CAS  Google Scholar 

  64. Silverman NA, Alexander JC Jr, Chretien PB. CEA levels in head and neck cancer. Cancer (37): 2204–2211, 1976.

    PubMed  CAS  Google Scholar 

  65. Osoba D, Kersey PA, Clark RM, Rosen IB. Prognostic value of skin testing with dinitro-chlorobenzene in patients with head and neck cancer. Can J Surg (23): 43–44, 1980.

    PubMed  CAS  Google Scholar 

  66. Molinari R. Study for a possible monitoring of radiosensitivity of oral and oropharyngeal carcinoma using evaluation of potential proliferative activity (L.I.). Proc. International Head and Neck Oncology Research Conference, Rosslyn, Virginia, Sept. 1980. Abstract 4.4.

    Google Scholar 

  67. Suit H, Lindberg R, Fletcher GH. Prognostic significance of extent of tumor regression at completion of radiation therapy. Radiology (84): 1100–1107, 1965.

    PubMed  CAS  Google Scholar 

  68. Fazekas JT, Green JP, Vaeth JM, Schroeder AF. Postirradiation induration as a prognosticator. A retrospective analysis of squamous-cell carcinomas of the oral cavity and oropharynx. Radiology (102): 409–412, 1972.

    PubMed  CAS  Google Scholar 

  69. Barkley HT Jr, Fletcher GH. The significance of residual disease after external irradiation of squamous-cell carcinoma of the oropharynx. Radiology (124): 493–495, 1977.

    PubMed  CAS  Google Scholar 

  70. Mantyla M, Kortekangas AE, Valavaara RA, Nordman EM. Tumor regression during radiation treatment as a guide to prognosis. Br J Radiol (52): 972–977, 1979.

    PubMed  CAS  Google Scholar 

  71. Sobel S, Rubin P, Keller B, Poulter C. Tumor persistence as a predictor of outcome after radiation therapy of head and neck cancers. Int J Radiat Oncol Biol Phys (1): 873–880, 1976.

    PubMed  CAS  Google Scholar 

  72. Taylor SG. Head and neck cancer. In Cancer Chemotherapy 1979, Annual 3, Pinedo HM (ed). New York: Elsevier, 1981, pp. 263–278.

    Google Scholar 

  73. Fazekas JT, Sommer C, Kramer S. Adjuvant intravenous methotrexate or definitive radiotherapy alone for advanced squamous cancers of the oral cavity, oropharynx, supraglottic larynx or hypopharynx. Int J Radiat Oncol Biol Phys (6): 533–541, 1980.

    PubMed  CAS  Google Scholar 

  74. Fu KK, Silverberg IJ, Phillips TL, Friedman MA. Combined radiotherapy and multidrug chemotherapy for advanced head and neck cancer: Results of a Radiation Therapy Oncology Group Pilot Study. Cancer Treat Rep (63): 351–357, 1979.

    PubMed  CAS  Google Scholar 

  75. Lo TCM, Wiley AL Jr, Ansfield FJ, Brandenburg JH, Davis HL Jr, Gollin FF, Johnson RO, Ramirez G, Vermund H. Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: A randomized study. AJR (126): 229–235, 1976.

    PubMed  CAS  Google Scholar 

  76. Elkind MM. Fundamental questions in the combined use of radiation and chemicals in the treatment of cancer. Int J Radiat Oncol Biol Phys (5): 1711–1720, 1979.

    PubMed  CAS  Google Scholar 

  77. Combined Modalities. Chemotherapy/radiotherapy—Meeting summary. Int J Radiat Oncol Biol Phys (5): 1721–1723, 1979.

    Google Scholar 

  78. Goldsmith MA, Carter SK. The integration of chemotherapy into a combined modality approach to cancer therapy. V. Squamous cell cancer of the head and neck. Cancer Treat Rev (2): 137–158, 1975.

    PubMed  CAS  Google Scholar 

  79. Fu KK. Normal tissue effects of combined radiotherapy and chemotherapy for head and neck cancer. Front Radiat Ther Oncol (13): 113–132, 1979.

    Google Scholar 

  80. Chassagne D, Richard JM, Le Floch O. Results of interstitial curietherapy in T3 and T4 floor of the mouth and tongue cancers after previous arterial infusion chemotherapy. Panminerva Med (18): 45–49, 1976.

    PubMed  CAS  Google Scholar 

  81. Cachin Y, Jortay A, Sancho H, Eschwege F, Madelain M, Desaulty A, Gerard P. Preliminary results of a randomized EORTC study comparing radiotherapy and concomitant bleomycin to radiotherapy alone in epidermoid carcinomas of the oropharynx. Eur J Cancer (13): 1389–1395, 1977.

    PubMed  CAS  Google Scholar 

  82. Shanta V, Krishnamurthi S. Combined bleomycin and radiotherapy in oral cancer. Clin Radiol (31): 617–620, 1980.

    PubMed  CAS  Google Scholar 

  83. O’Connor AD, Clifford P, Dalley VM, Durden-Smith DJ, Edwards WG, Hollis BA. Advanced head and neck cancer treated by combined radiotherapy and VBM cytotoxic regimen—four-year results. Clin Otolaryngol (4): 329–337, 1979.

    PubMed  Google Scholar 

  84. Gray LH, Conger AD, Ebert M, Hornsey S, Scott OCA. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol (26): 638–648, 1953.

    PubMed  CAS  Google Scholar 

  85. Rubin P, Hanley J, Keys HM, Marcial V, Brady L. Carbogen breathing during radiation therapy. Int J Radiat Oncol Biol Phys (5): 1963–1970, 1979.

    PubMed  CAS  Google Scholar 

  86. Henk JM, Kunkler PB, Smith CW. Radiotherapy and hyperbaric oxygen in head and neck cancer. Final report of first controlled clinical trial. Lancet (II): 101–103, 1977.

    Google Scholar 

  87. Medical Research Council Working Party. Radiotherapy and hyperbaric oxygen. Lancet (II): 881–884, 1978.

    Google Scholar 

  88. Dische S. Hyperbaric oxygen: The Medical Research Council trials and their clinical significance. Br J Radiol (51): 888–894, 1979.

    Google Scholar 

  89. Raju MR. Heavy Particle Radiotherapy. London: Academic Press, 1980.

    Google Scholar 

  90. Catterall M, Bewley DK. Fast Neutrons in The Treatment of Cancer. New York: Academic Press, 1979.

    Google Scholar 

  91. Griffin TW, Weisberger EC, Laramore GE, Tong D, Blasko JC. Complications of combined surgery and neutron radiation therapy in patients with advanced carcinoma of the head and neck. Radiology (132): 177–178, 1979.

    PubMed  CAS  Google Scholar 

  92. L.W. Brady (ed). Radiation Sensitizers, Their Use in The Clinical Management of Cancer. Masson Publishing U.S.A., 1980.

    Google Scholar 

  93. Denekamp J, McNally NJ, Fowler JF, Joiner MC. Misonidazole in radiotherapy: Are many small fractions best? Br J Radiol (53): 981–990, 1980.

    PubMed  CAS  Google Scholar 

  94. Fazekas JT, Goodman RL, McLean CJ. The value of adjuvant misonidazole in the definitive irradiation of advanced head and neck squamous cancer. An RTOG pilot study (78–02). Int J Radiat Oncol Biol Phys (7): 1703–1708, 1981.

    PubMed  CAS  Google Scholar 

  95. Sealy R, Williams A, Levin W, Blair R, Flockhart I, Stratford M, Minchinton A, Cridland S. Progress in investigations in the use of misonidazole in head and neck cancer as a hypoxic cell Radiation sensitizer and in combination with hyperbaric oxygen or hyperthermia. In Radiation Sensitizers: Their Use in the Clinical Management of Cancer, Brady LW (ed). Masson Publishing U.S.A., 1980, pp. 361–365.

    Google Scholar 

  96. Bush RS, Jenkin RDT, Allt WEC, Beale FA, Bean H, Dembo AJ, Pringle JF. Definitive evidence for hypoxic cells influencing cure in cancer therapy. Br J Cancer (37) (Suppl III): 302–306, 1978.

    Google Scholar 

  97. Siemann DW, Hill RP, Bush RS. Smoking: The influence of carboxyhemoglobin (HbCO) on tumor oxygenation and response to Radiation. Int J Radiat Oncol Biol Phys (4): 657–662, 1978.

    PubMed  CAS  Google Scholar 

  98. Pierquin BM, Mueller WK, Baillet F. Low dose rate ir Radiation of advanced head and neck cancers: Present status. Int J Radiat Oncol Biol Phys (4): 565–572, 1978.

    PubMed  CAS  Google Scholar 

  99. Shukovsky LJ, Fletcher GH, Montague ED, Withers HR. Experience with twice-a-day fractionation in clinical radiotherapy. AJR (126): 155–162, 1976.

    PubMed  CAS  Google Scholar 

  100. Backström A, Jakobsson PA, Littbrand B, Wersall J. Fractionation scheme with low individual doses in irradiation of carcinoma of the mouth. Acta Radiol (Ther) (12): 401–406, 1973.

    Google Scholar 

  101. Peracchia G, Salti C. Radiotherapy with thrice-a-day fractionation in a short overall time: Clinical experiences. Int J Radiat Oncol Biol Phys (7): 99–104, 1981.

    PubMed  CAS  Google Scholar 

  102. Au SC, Archambeau JO. Continuous external irradiation. Int J Radiat Oncol Biol Phys (5): 253–255, 1979.

    PubMed  CAS  Google Scholar 

  103. Holsti LR. Clinical experience with split-course radiotherapy. A randomized clinical trial. Radiology (92): 591–596, 1969.

    PubMed  CAS  Google Scholar 

  104. Abramson N, Scruggs RP, Cavanaugh PJ. Short-course radiation therapy in the treatment of head and neck tumors. Radiology (118): 175–178, 1976.

    PubMed  CAS  Google Scholar 

  105. Pilepich MV, Munzenrider JE, Rene JB. Unorthodox fractionation in the treatment of head and neck tumors. Int J Radiat Oncol Biol Phys (5): 249–252, 1979.

    PubMed  CAS  Google Scholar 

  106. Million RR, Zimmermann RC. Evaluation of University of Florida split-course technique for various head and neck squamous cell carcinomas. Cancer (35): 1533–1536, 1975.

    PubMed  CAS  Google Scholar 

  107. Wang CC. Radiation therapy in the management of oral malignant disease. Otolaryngol Clin North Am (12): 73–80, 1979.

    PubMed  CAS  Google Scholar 

  108. Harwood AR, Cummings BJ. Radiotherapy for mucosal melanomas. Int J Radiat Oncol Biol Phys (8): 1121–1126, 1982.

    PubMed  CAS  Google Scholar 

  109. Rubin P, Casarett GW. Clinical Radiation Pathology. Philadelphia: W.B. Saunders, 1968.

    Google Scholar 

  110. Beumer J III, Curtis T, Harrison RE. Radiation therapy of the oral cavity: Sequelae and management, Part 1. Head Neck Surg (1): 301–312, 1979.

    PubMed  Google Scholar 

  111. Beumer J, Curtis T, Harrison RE. Radiation therapy of the oral cavity: Sequelae and management, Part 2. Head Neck Surg (1): 392–408, 1979.

    PubMed  Google Scholar 

  112. Phillips TL. Rationale for initial clinical trials and future development of radioprotectors. Cancer Clin Trials (3): 165–173, 1980.

    PubMed  CAS  Google Scholar 

  113. Starcke EN, Shannon IL. How critical is the interval between extractions and irradiation in patients with head and neck malignancy? Oral Surg (43): 333–337, 1977.

    PubMed  CAS  Google Scholar 

  114. Daley TE, Drane JB. Management of Dental Problems in Irradiated Patients. Houston: University of Texas Press, 1972.

    Google Scholar 

  115. Carl W, Schaaf NG. Dental care for the cancer patient. J Surg Oncol (6): 293–310, 1974.

    PubMed  CAS  Google Scholar 

  116. Murray CG, Herson J, Daly TE, Zimmerman S. Radiation necrosis of the mandible: A 10-year study. Part I. Factors influencing the onset of necrosis. Int J Radiat Oncol Biol Phys (6): 543–548, 1980.

    PubMed  CAS  Google Scholar 

  117. Murray CG, Herson J, Daly TE, Zimmerman S. Radiation necrosis of the mandible: A 10-year study. Part II. Dental factors; onset, duration and management of necrosis. Int J Radiat Oncol Biol Phys (6): 549–553, 1980.

    PubMed  CAS  Google Scholar 

  118. Murray CG, Daly TE, Zimmerman SO. The relationship between dental disease and radiation necrosis of the mandible. Oral Surg (49): 99–104, 1980.

    PubMed  CAS  Google Scholar 

  119. Davis JC, Dunn JM, Gates GA, Heimbach RD. Hyperbaric oxygen: A new adjunct in the management of radiation necrosis. Arch Otolaryngol (105): 58–61, 1979.

    PubMed  CAS  Google Scholar 

  120. Joseph DL, Shumrick DL. Risks of head and neck surgery in previously irradiated patients. Arch Otolaryngol (97): 381–384, 1973.

    PubMed  CAS  Google Scholar 

  121. Donaldson SS. Nutritional consequences of radiotherapy. Cancer Res (37): 2407–2413, 1977.

    PubMed  CAS  Google Scholar 

  122. Sobol SM, Conoyer JM, Zill R, Thawley SE, Ogura JH. Nutritional concepts in the management of the head and neck cancer patient. II. Management concepts. Laryngoscope (89): 962–979, 1979.

    PubMed  CAS  Google Scholar 

  123. Wynder EL, Dodo H, Bloch DA, Gantt RC, Moore OS. Epidemiologic investigation of multiple primary cancer of the upper alimentary and respiratory tracts. I. A retrospective study. Cancer (24): 730–739, 1969.

    PubMed  CAS  Google Scholar 

  124. Kogelnik HD, Fletcher GH, Jesse RH. Clinical course of patients with squamous cell carcinoma of the upper respiratory and digestive tracts with no evidence of disease 5 years after initial treatment. Radiology (115): 423–427, 1975.

    PubMed  CAS  Google Scholar 

  125. Cummings BJ, Clark RM. Cancer of the oral cavity. J Otolaryngol (11): 359–364, 1982.

    PubMed  CAS  Google Scholar 

  126. Decroix Y, Ghossein NA. Experience of the Curie Institute in treatment of cancer of the mobile tongue. II Management of the neck nodes. Cancer (47): 503–508, 1981.

    PubMed  CAS  Google Scholar 

  127. Glick JH, Taylor SG. Integration of chemotherapy into a combined modality treatment plan for head and neck cancer: A review. Int J Radiat Oncol Biol Phys (7): 229–242, 1981.

    PubMed  CAS  Google Scholar 

  128. Duncan W, Arnott SJ, Orr JA, Kerr GR. The Edinburgh experience of fast neutron therapy. Int J Radiat Oncol Biol Phys (8): 2155–2157, 1982.

    PubMed  CAS  Google Scholar 

  129. Griffin TW, Lawrence GE, Hussey DH, Hendrickson FR, Rodriguez-Antunez A. Fast neutron beam radiation therapy in the United States. Int J Radiat Oncol Biol Phys (8): 2165–2168, 1982.

    PubMed  CAS  Google Scholar 

  130. Phillips TL, Wasserman TH, Stetz J, Brady LW. Clinical trials of hypoxic cell sensitizers. Int J Radiat Oncol Biol Phys (8): 327–334, 1982.

    PubMed  CAS  Google Scholar 

  131. Cummings BJ, Thomas GM, Rauth AM, Sorrenti V, Black B, Bush RS. Neurotoxic radiosensitizers and head and neck cancer patients — how many will benefit? Int J Radiat Oncol Biol Phys (8): 343–345, 1982.

    PubMed  CAS  Google Scholar 

  132. Kotalik JF. Multiple daily fractions in radiotherapy. Cancer Treat Rev (8): 127–146, 1981.

    PubMed  CAS  Google Scholar 

  133. Withers HR, Peters LJ, Thames HD, Fletcher GH. Hyperfractionation. Int J Radiat Oncol Biol Phys (8): 1807–1809, 1982.

    PubMed  CAS  Google Scholar 

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Authors
  1. B. J. Cummings
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Editors and Affiliations

  1. Department of Oral Pathology, Free University Hospital, 1117 de Boelelaan, 1007 MB, Amsterdam, The Netherlands

    I. van der Waal (Professor and Head) & G. B. Snow (Professor and Head) (Professor and Head) &  (Professor and Head)

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© 1984 Martinus Nijhoff Publishing, Boston

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Cummings, B.J. (1984). Radiotherapy Aspects of Malignant Diseases of the Oral Cavity. In: van der Waal, I., Snow, G.B. (eds) Oral Oncology. Developments in Oncology, vol 20. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-2845-2_6

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  • DOI: https://doi.org/10.1007/978-1-4613-2845-2_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-9796-3

  • Online ISBN: 978-1-4613-2845-2

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