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Endothelins in breast cancer

  • Chapter
Mammary Tumor Cell Cycle, Differentiation, and Metastasis

Part of the book series: Cancer Treatment and Research ((CTAR,volume 83))

Abstract

Just how the normally ordered regime of growth and differentiation executed by all cells is over-riden, leading to the transformed phenotype, is as yet not fully understood, but many consider this progression to be a multistep process involving the accumulation of a number of genetic lesions, that is, loss of tumor suppressor genes or proto-oncogene activation [1–3]. Indeed, cytogenetic analysis of human malignant cells has shown that at least 90% of human tumors examined carry some form of cytogenetic alteration [4].

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Authors
  1. Kirti V. Patel
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  2. Michael P. Schrey
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Editors and Affiliations

  1. Departments of Cell Biology and Pharmacology, Lombardi Cancer Center, The Research Building, 3970 Reservoir Road, 20007, Washington, DC, USA

    Robert B. Dickson PHD

  2. Departments of Medicine and Pharmacology, Lombardi Cancer Center, The Research Building, 20007, 3970 Reservoir Road, Washington, CD, USA

    Marc E. Lippman MD

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© 1996 Kluwer Academic Publishers

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Patel, K.V., Schrey, M.P. (1996). Endothelins in breast cancer. In: Dickson, R.B., Lippman, M.E. (eds) Mammary Tumor Cell Cycle, Differentiation, and Metastasis. Cancer Treatment and Research, vol 83. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1259-8_18

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  • DOI: https://doi.org/10.1007/978-1-4613-1259-8_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8536-6

  • Online ISBN: 978-1-4613-1259-8

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