Abstract
It is well established that the α-adrenergic system plays a primary role in the regulation of growth hormone (GH) release in humans and animals (1–3). As far as the site of action of α-adrenergic agents is concerned, the high levels of epinephrine in the portal circulation (4) as well as the identification of a α1-adrenergic receptors in the pituitary gland, point to the possible direct effect of adrenergic agents on hormone release. However, studies with isolated anterior pituitary cells have yielded rather conflicting results: α-adrenergic drugs have been reported either to inhibit, stimulate or not to influence GH release from pituitary cells in culture (3). With respect to the mechanisms of action of α-adrenergic agents, in all the systems so far studied, such as vascular smooth muscle cells, hepatocytes and myocardial cells, α1 adrenergic agents have been demonstrated to increase cytosolic free Ca2+ concentrations (5–7).
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© 1989 Springer-Verlag New York Inc.
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Pandiella, A., Elahi, F.R., Vallar, L., Spada, A. (1989). Alpha-1-Adrenergic Stimulation of Cytosolic Ca2+ Concentration and Growth Hormone (GH) in Rat Somatotrophs. In: Wass, J.A.H., Scanlon, M.F. (eds) Neuroendocrine Perspectives. Neuroendocrine Perspectives, vol 6. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3478-4_24
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DOI: https://doi.org/10.1007/978-1-4612-3478-4_24
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