Abstract
In the early days of blood and marrow transplantation (BMT), the rationale for the procedure was to administer high doses of chemotherapy or radiation therapy (or both) to patients in an attempt to eradicate their underlying disease and then rescue them with blood or marrow progenitors to shorten the period of cytopenias after such high-dose therapy. Although this principle is still pertinent today, new knowledge of the immune system has extended our understanding of how BMT can treat human disease.
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Further Reading
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Winter JN (editor) Blood stem cell transplantation. Boston: Kluwer Academic Publishers, 1997.
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Litzow, M.R. (2001). Blood and Marrow Transplantation. In: Hakim, N.S., Danovitch, G.M. (eds) Transplantation Surgery. Springer Specialist Surgery Series. Springer, London. https://doi.org/10.1007/978-1-4471-3689-7_14
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