Abstract
About 15% (11%–23%) of all ischemic strokes are caused by cardiogenic embolism (Mohr et al. 1978; Wolf et al. 1983; Caplan et al. 1983; Herman et al. 1982; Chambers et al. 1983). Since many potential cardiogenic sources of emboli are identifiable prior to stroke, prevention would seem possible. However, two major problems limit preventive efforts. First, only a fraction of patients with cardiac disorders predisposing to embolism experience embolic stroke (Table 7.1). Unless subgroups of patients at particularly high risk for stroke can be identified, many patients with potentially emboligenic heart disease will need to be treated to prevent stroke that is destined to occur in only a small minority. Second, currently available prophylactic treatments, both medical and surgical, either carry a substantial risk or are of unproven benefit. So despite burgeoning clinical data suggesting that one in six ischemic strokes is due to cardiogenic embolism, effective preventive measures have been largely lacking.
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Hart, R.G. (1987). Prevention and Treatment of Cardioembolic Stroke. In: Furlan, A.J. (eds) The Heart and Stroke. Clinical Medicine and the Nervous System. Springer, London. https://doi.org/10.1007/978-1-4471-3129-8_7
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