Abstract
Lipoprotein [a] or Lp [a] represents a class of lipoprotein particles associated with an increased prevalence of atherosclerotic cardiovascular disease (ASGVD) (Utermann 1989; Scanu and Fless 1990; Berg 1990). At this time this notion rests predominantly on epidemiological data although emerging experimental evidence is now permitting to formulate hypotheses on the possible mechanism(s) of this pathogenicity. This experimental evidence will be reviewed and correlated with the current understanding of the structural properties of Lp[a].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Berg K (1990) Lp(a) lipoprotein: an overview. In: Scanu AM (ed) Lipoprotein(a). Academic Press, San Diego, pp 1–23
Brewer HB (1990) Effectiveness of diet and drugs in the treatment of patients with elevated Lp(a) levels. In: Scanu AM (ed) Lipoprotein(a). Academic Press, San Diego, pp 211–220
Carlson LA, Mansten A, Asplund A (1989) Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nictotinic acid. J Intern Med 226:271–276
Cushing GL, Gaubatz JW, Nava ML, Burdick BJ, Bocan TMA, Guyton JR, Weilbaecher D, DeBakey ME, Lawrie GM, Morrisett JD (1989) Quantitation and localization of apolipo-protein(a) and B in coronary artery bypass vein grafts resected at re-operation. Arteriosclerosis 9:593–603
Fless GM, Pfaffinger DJ, Eisenbart TD, Scanu AM (1990) Solubility, immunochemical and lipoprotein binding properties of apoB100-apo(a), the protein moiety of lipoprotein (a). J Lipid Res 31:909–918
Haberland ME, Fless GM, Scanu AM, Fogelman AM (1989) Modification of Lp(a) by malondialdehyde leads to avid uptake by human monocyte-macrophages. Arteriosclerosis 9:700a
Loscalzo J (1990) Lipoprotien(a): a unique risk factor for atherothrombotic disease. Arteriosclerosis 10:672–679
McLean JW, Tomlinson JE, Kuang W, Eaton DL, Chen EY, Fless GM, Scanu AM, Lawn RM (1987) cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature 330:132–137
Rath MS, Niendorf A, Reblin T, Dietel M, Krebber JH, Beisigel U (1989) Detection and quantification of lipoprotein(a) in the arterial wall of 107 coronary bypass patients. Arteriosclerosis 9:570–592
Scanu AM (1990) Lipoprotein(a): A genetically determined cardiovascular pathogen in search of a function. J Lab Clin Med 116:142–146
Scanu AM, Fless GM (1990) Lipoprotein(a): heterogeneity and biological relevance. J Clin Invest 85:1709–1715
Seed M, Hoppichler F, Reaveley D, McCarthey S, Thompson GR, Boerwinkle E, Utermann G (1990) Relation of serum lipoprotein(a) concentration and apolipoprotein(a) phenotype to coronary heart disease in patients with familial hypercholesterolemia. N Engl J Med 322:1494–1496
Snyder ML, Fless GM, Polacek D, Scanu AM (1990) Human monocyte derived macrophages degrade Lp(a) differently than LDL. Arteriosclerosis 10:908a
Sorrentino M, Vielhauer C, Fless GM, Scanu AM, Feldman T (1990) Paradoxical difference in plasma lipoprotein(a) levels in white patients with two and three vessel coronary artery disease. Arteriosclerosis 10:829a
Utermann G (1989) The mysteries of lipoprotein(a). Science 246:904–910
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag London Limited
About this chapter
Cite this chapter
Scanu, A.M. (1992). Lp [a]: A Lipoprotein Class with Atherothrombotic Potential. In: Gotto, A.M. (eds) Cellular and Molecular Biology of Atherosclerosis. Argenteuil Symposia. Springer, London. https://doi.org/10.1007/978-1-4471-1909-8_6
Download citation
DOI: https://doi.org/10.1007/978-1-4471-1909-8_6
Publisher Name: Springer, London
Print ISBN: 978-1-4471-1911-1
Online ISBN: 978-1-4471-1909-8
eBook Packages: Springer Book Archive