SpringerLink
Log in

Chemotherapy in Disseminated Testicular Cancer

  • Chapter
Combination Therapy in Urological Malignancy

Part of the book series: Clinical Practice in Urology ((PRACTICE UROLOG))

  • 48 Accesses

Abstract

Testicular germ cell tumours can be divided into seminomas and non-seminomas. Seminomas are radiosensitive and approximately 90% can be cured with radiotherapy since, in the majority of cases, the disease is limited to the testis with or without small metastases in the retroperitoneal lymph nodes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

eBook
USD 9.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free ship** worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  • Birch R, Williams S, Cone A, Einhorn L, Roark P, Turner S, Greco F (1986) Prognostic factors for favorable outcome in disseminated germ cell tumours. J Clin Oncol 4: 400–407

    PubMed  CAS  Google Scholar 

  • Bosl GJ, Geller NL, Cirrincione C, Vogelzang NJ, Kennedy BJ, Whitmore WFJr, Vugrin D, Scher H, Nisselbaum J, Golbey RB (1983) Multivariate analysis of prognostic variables in patients with metastatic testicular cancer. Cancer Res 43: 3403–3407

    PubMed  CAS  Google Scholar 

  • Bosl GJ, Gluckman R, Geller, NL, Golbey RB, Whitmore WF, Herr H, Sogani P, Morse M, Martini N, Bains M, McCormack P (1986) VAB-6: an effective chemotherapy regimen for patients with germ cell tumors. J Clin Oncol 4: 1493–1499

    PubMed  CAS  Google Scholar 

  • Bosl GJ, Geller NL, Vogelzang NJ, Carey R, Auman J, Whitmore WF, Herr H, Morse M, Sogani P, Chan E (1987) Alternating cycles of etoposide plus cisplatin and VAB-6 in the treatment of poor-risk patients with germ cell tumors. J Clin Oncol 5: 436–440

    PubMed  CAS  Google Scholar 

  • Brada M, Horwich A, Peckham MJ (1987) Treatment of favorable-prognosis nonseminomatous testicular germ cell tumors with etoposide, cisplatin, and reduced dose of bleomycin. Cancer Treat Rep 71: 655–656

    PubMed  CAS  Google Scholar 

  • Cavalli F, Klepp O, Renard J, Rohrt M, Alberto P (1981) A phase II study of oral W-16–213 in nonseminomatous testicular cancer. Eur J Cancer 17: 245–249

    Article  PubMed  CAS  Google Scholar 

  • Cheng E, Cvitkovic E, Wittes RE, Golbey RB (II) (1978) VAB II in metastatic testicular cancer. Cancer 42: 2162–2168

    Article  PubMed  CAS  Google Scholar 

  • Daugaard G, Hansen HH, Rath (1987) Management of advanced metastatic germ cell tumours. Int J Androl 10: 319–324

    CAS  Google Scholar 

  • Einhorn LH (1987) Treatment strategies of testicular cancer in the US. Int J Androl 10: 399–405

    Article  PubMed  CAS  Google Scholar 

  • Einhorn LH, Donohue JP (1977) Cis-diamminedichloroplatinum, vinblastine and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med 87: 293–298

    PubMed  CAS  Google Scholar 

  • Einhorn LH, Williams SD (1980) Chemotherapy of disseminated testicular cancer. Cancer 46: 1339–1344

    Article  PubMed  CAS  Google Scholar 

  • Einhorn LH, Williams SD, Troner M, Birch R, Greco FA (1981) The role of maintenance therapy in disseminated testicular cancer. N Engl J Med 305: 727–731

    Article  PubMed  CAS  Google Scholar 

  • Gregory C, Peckham MJ (1986) Results of radiotherapy for stage II testicular seminoma. Radiother Oncol 6: 285–292

    Article  PubMed  CAS  Google Scholar 

  • Hainsworth JD, Greco FA (1983) Testicular germ cell neoplasms. Am J Med 75: 817–832

    Article  PubMed  CAS  Google Scholar 

  • Higby DJ, Wallace HJ, Albert DJ, Holland JF (1974) Diamminedichloroplatinum: a phase I study showing response in testicular and other tumors. Cancer 33: 1219–1225

    Article  PubMed  CAS  Google Scholar 

  • Hubbard SM, McDonald JS (1982) An introduction to current controversies in cancer management: stage I testicular cancer — A case in point. Cancer Treat Rep 66: 1–3

    PubMed  CAS  Google Scholar 

  • Li MC, Whitmore WF, Golbey R, Grabstald H (1960) Effect of combined drug therapy on metastatic cancer of the testis. JAMA 174: 1291–1299

    CAS  Google Scholar 

  • Loehrer PJ, Einhorn LH, Williams SD (1985) Salvage therapy for refractory germ cell tumors (RGCT) with VP-16 plus ifosfamide (IFX) plus cisplatin ( DDP ). Proc Am Soc Clin Oncol 4: 100

    Google Scholar 

  • Loehrer PJ, Birch R, Williams SD, Greco FA, Einhorn LH (1987) Chemotherapy of metastatic seminoma: The Southeastern Cancer Study Group Experience. J Clin Oncol 5: 1212–1220

    Google Scholar 

  • Medical Research Council Working Party on Testicular Tumours (1985) Prognostic factors in advanced non-seminomatous germ-cell testicular tumours: results of a multicentre study. Lancet I: 8–11

    Google Scholar 

  • Oliver RTD (1984) Surveillance for stage I seminoma and single agent cisplatinum for metastatic seminoma. Proc Am Soc Clin Oncol 3: 162

    Google Scholar 

  • Oliver RTD (1987) Limitations to the case of surveillance as an option in the management of stage I seminoma. Int J Androl 10: 263–268

    Article  PubMed  CAS  Google Scholar 

  • Oosterom AT van, Williams SD, Cortes Funes H, ten Bokkel Huinink WW, Vendrik CP, Einhorn LH (1985) Treatment of seminomas with combination chemotherapy. In: Jones WG, Milford Ward A, Anderson CK (eds) Germ cell tumors II. Pergamon Press, Oxford, pp 229–233

    Google Scholar 

  • Ozols RF (1987) Treatment of poor prognosis germ cell tumors with high dose cisplatin regimens. Int J Androl 10: 291–300

    Article  PubMed  CAS  Google Scholar 

  • Peckham MJ, Barrett A, McElwain TJ, Hendry WF (1979) Combined management of malignant teratoma of the testis. Lancet II: 267–270

    Google Scholar 

  • Peckham MJ, Horwich A, Hendry WF (1985) Advanced seminoma: treatment with cisplatinumbased combination chemotherapy or carboplatin (JM8). Br J Cancer 52: 7–13

    Article  PubMed  CAS  Google Scholar 

  • Pico JL, Droz JP, Couyette A, Beaujean F, Baume D, Amiel J, Hayat M (1986) High dose chemotherapy followed by autologous bone marrow transplantation for poor prognosis nonseminomatous germ cell tumors. Proc Am Soc Clin Oncol 5: 111

    Google Scholar 

  • Pizzocaro G (1985a) Personal experience in the management of germinal testis tumors. Acta Urologica Belgica 53: 249–258

    Google Scholar 

  • Pizzocaro G, Luigi P, Salvioni R, Zanoni F, Milani A (1985b) Cisplatin, etoposide, bleomycin first-line therapy and early resection of residual tumor in far-advanced germinal testis cancer. Cancer 56: 2411–2415

    Article  PubMed  CAS  Google Scholar 

  • Samuels ML, Johnson DE, Holoye PY (1975) Continuous intravenous bleomycin therapy with vinblastine in stage III testicular neoplasia. Cancer Chemother Rep 59: 563–570

    PubMed  CAS  Google Scholar 

  • Schmoll HJ, Schubert I, Arnold H, Dölken G, Hecht Th, Bergman L, Illiger J, Fink U, Preiss J, Pfreudschuh M, Kaulen H, Bonfert B, Ho AD, Manegold C, Mayr A, Hoffman L, Weiss J, Hecker H (1987) Disseminated testicular cancer with bulky disease: results of a phase-II study with cisplatin ultra high dose/VP-16/bleomycin. Int J Androl 10: 311–317

    Article  PubMed  CAS  Google Scholar 

  • Stoter G, Sleijfer DTh, Vendrik CP, Schraffordt Koops H, Struyvenberg A, van Oosterom AT, Brouwers TM, Pinedo HM (1979) Combination chemotherapy with cis-diamminedichloroplatinum, vinblastine and bleomycin in advanced testicular nonseminomas. Lancet I: 941–945

    Google Scholar 

  • Stoter G, Sleijfer DTh, Bokkel Huinink WW ten, Kaye SB, Jones WG, Oosterom AT van, Vendrik CP, Spaander P, Pauw M de, Sylvester R (1986a) High dose versus low dose vinblastine in cisplatin-vinblastine-bleomycin combination chemotherapy of non-seminomatous testicular cancer: a randomized study of the EORTC Genitourinary Tract Cancer Cooperative Group. J Clin Oncol 4: 1199–1206

    PubMed  CAS  Google Scholar 

  • Stoter G, Kaye S, Sleijfer DTh, Bokkel Huinink WW ten, Jones WG, Oosterom AT van, Splinter T, Pinedo HM, Sylvester R, Keizer J (1986b) Preliminary results of BEP versus an alternating regimen of BEP and PVB in high volume metastatic testicular non-seminomas. An EORTC study. Proc Am Soc Clin Oncol 5: 106

    Google Scholar 

  • Stoter G, Kaye S, Jones WG, Bokkel Huinink WW ten, Sleijfer DTh, Splinter T, Oosterom AT van, Harris A, Boven E, Pauw M de, Sylvester R (1987a) Cisplatin and VP-16 in good risk patients with disseminated non-seminomatous testicular cancer: a randomized EORTC GU group study. Proc Am Soc Clin Oncol 6: 110

    Google Scholar 

  • Stoter G, Sylvester R, Sleijfer DTh, Bokkel Huinink WW ten, Kaye SB, Jones WG, Oosterom AT van, Vendrik CP, Spaander P, Pauw M de (1987b) Multivariate analysis of prognostic factors in patients with disseminated non-seminomatous testicular cancer. Cancer Res 47: 2714–2718

    PubMed  CAS  Google Scholar 

  • Williams S, Birch R, Einhorn L, Irwin L, Greco A, Loehrer RI (1987) Treatment of disseminated germ cell tumors with cisplatin, bleomycin and either vinblastine or etoposide. New Engl J Med 316: 1435–1440

    Article  PubMed  CAS  Google Scholar 

  • Wettlaufer JN, Feiner AS, Robinson WA (1984) Vincristine, cisplatin, and bleomycin with surgery in the management of advanced metastatic nonseminomatous testis tumors. Cancer 53: 203–209

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. C. J. Rodenburg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Stoter
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. St James’s University Hospital, Beckett Street, LS9 7TF, Leeds, UK

    Philip H. Smith MB, FRCS (Consultant Urologist) (Consultant Urologist)

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rodenburg, C.J., Stoter, G. (1989). Chemotherapy in Disseminated Testicular Cancer. In: Smith, P.H. (eds) Combination Therapy in Urological Malignancy. Clinical Practice in Urology. Springer, London. https://doi.org/10.1007/978-1-4471-1655-4_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4471-1655-4_10

  • Publisher Name: Springer, London

  • Print ISBN: 978-1-4471-1657-8

  • Online ISBN: 978-1-4471-1655-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation