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Endothelins in Bone Cancer Metastases

  • Chapter
The Biology of Skeletal Metastases

Part of the book series: Cancer Treatment and Research ((CTAR,volume 118))

Abstract

Since their isolation in 1988, endothelins have emerged as modulators of many functions including vasomotor tone, hormone production and cell proliferation. Endothelins and their receptors are expressed by many tissues, thus, it is no surprise that endothelins play an important role in the normal physiological functions and pathological states. Abundant evidence implicates a role for endothelins in cancer. This review will present evidence that endothelins play a major role in the process of cancer metastases to bone.

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  1. Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, Virginia, USA

    Theresa A. Guise & Khalid S. Mohammad

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  1. University of Michigan Comprehensive Cancer Center University of Michigan School of Medicine, University of Michigan, Ann Arbor, Michigan, USA

    Evan T. Keller DVM, PhD (Associate Professor of Urology, Comparative Medicine and Pathology) (Associate Professor of Urology, Comparative Medicine and Pathology)

  2. Emory University School of Medicine, Emory University, Atlanta, Georgia, USA

    Leland W. K. Chung PhD (Professor of Urology, Hematology/Oncology, Biochemistry and the Winship Cancer Institute) (Professor of Urology, Hematology/Oncology, Biochemistry and the Winship Cancer Institute)

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Guise, T.A., Mohammad, K.S. (2004). Endothelins in Bone Cancer Metastases. In: Keller, E.T., Chung, L.W.K. (eds) The Biology of Skeletal Metastases. Cancer Treatment and Research, vol 118. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9129-4_9

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  • DOI: https://doi.org/10.1007/978-1-4419-9129-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4803-0

  • Online ISBN: 978-1-4419-9129-4

  • eBook Packages: Springer Book Archive

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