Scleroderma Mimics

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Scleroderma
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Abstract

Scleroderma is an uncommon condition, but has features that are commonly encountered in a general population such as Raynaud’s phenomenon and gastroesophageal reflux. Therefore, having an appropriate level of suspicion for the diagnosis will help facilitate getting them to the appropriate specialist. However, there are other patients who present with features considered to be typical of scleroderma, such as Raynaud’s and skin thickening, who may have a syndrome mimicking scleroderma. So familiarity with these mimickers is critical for rheumatologists of other physicians who evaluate patients with scleroderma. Raynaud’s phenomenon and digital ischemia can be associated with multiple different etiologies, rheumatic and non-rheumatic and should be considered even in scleroderma patients with atypical findings (i.e., isolated toe ischemia).

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References

  1. Gelber AC, Wigley FM, Stallings RY, et al. Symptoms of Raynaud’s phenomenon in an inner-city African-American community: prevalence and self-reported cardiovascular comorbidity. J Clin Epidemiol. 1999;52(5):441–6.

    Article  PubMed  CAS  Google Scholar 

  2. Jones GT, Herrick AL, Woodham SE, Baildam EM, Macfarlane GJ, Silman AJ. Occurrence of Raynaud’s phenomenon in children ages 12–15 years: prevalence and association with other common symptoms. Arthritis Rheum. 2003;48(12):3518–21.

    Article  PubMed  Google Scholar 

  3. Voulgari PV, Alamanos Y, Papazisi D, Christou K, Papanikolaou C, Drosos AA. Prevalence of Raynaud’s phenomenon in a healthy Greek population. Ann Rheum Dis. 2000;59(3):206–10.

    Article  PubMed  CAS  Google Scholar 

  4. Maricq HR, Carpentier PH, Weinrich MC, et al. Geographic variation in the prevalence of Raynaud’s phenomenon: a 5 region comparison. J Rheumatol. 1997;24(5):879–89.

    PubMed  CAS  Google Scholar 

  5. Koenig M, Joyal F, Fritzler MJ, et al. Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud’s phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis. Arthritis Rheum. 2008;58(12):3902–12.

    Article  PubMed  Google Scholar 

  6. Liu A, Zhang W, Tian X, Zhang X, Zhang F, Zeng X. Prevalence, risk factors and outcome of digital gangrene in 2684 lupus patients. Lupus. 2009;18(12):1112–8.

    Article  PubMed  CAS  Google Scholar 

  7. Kalluri M, Sahn SA, Oddis CV, et al. Clinical profile of anti-PL-12 autoantibody. Cohort study and review of the literature. Chest. 2009;135(6):1550–6.

    Article  PubMed  CAS  Google Scholar 

  8. Glendenning JL, Barbachano Y, Norman AR, Dearnaley DP, Horwich A, Huddart RA. Long-term neurologic and peripheral vascular toxicity after chemotherapy treatment of testicular cancer. Cancer. 2010;116(10):2322–31.

    PubMed  CAS  Google Scholar 

  9. Maricq HR, Johnson MN, Whetstone CL, LeRoy EC. Capillary abnormalities in polyvinyl chloride production workers. Examination by in vivo microscopy. Jama. 1976;236(12):1368–71.

    Article  PubMed  CAS  Google Scholar 

  10. Rustin MH, Bull HA, Ziegler V, et al. Silica-associated systemic sclerosis is clinically, serologically and immunologically indistinguishable from idiopathic systemic sclerosis. Br J Dermatol. 1990;123(6):725–34.

    Article  PubMed  CAS  Google Scholar 

  11. Belongia EA, Hedberg CW, Gleich GJ, et al. An investigation of the cause of the eosinophilia-myalgia syndrome associated with tryptophan use. N Engl J Med. 1990;323(6):357–65.

    Article  PubMed  CAS  Google Scholar 

  12. Kaufman LD, Krupp LB. Eosinophilia-myalgia syndrome, toxic-oil syndrome, and diffuse fasciitis with eosinophilia. Curr Opin Rheumatol. 1995;7(6):560–7.

    Article  PubMed  CAS  Google Scholar 

  13. Kilbourne EM, Posada de la Paz M, Abaitua Borda I, Diez Ruiz-Navarro M, Philen RM, Falk H. Toxic oil syndrome: a current clinical and epidemiologic summary, including comparisons with the eosinophilia-myalgia syndrome. J Am Coll Cardiol. 1991;18(3):711–7.

    Article  PubMed  CAS  Google Scholar 

  14. Fonseca E, Contreras F. Cutaneous mucinosis in the toxic oil syndrome. J Am Acad Dermatol. 1987;16(1 Pt 1):139–40.

    Article  PubMed  CAS  Google Scholar 

  15. Cowper SE, Robin HS, Steinberg SM, Su LD, Gupta S, LeBoit PE. Scleromyxoedema-like cutaneous diseases in renal-dialysis patients. Lancet. 2000;356(9234):1000–1.

    Article  PubMed  CAS  Google Scholar 

  16. Cole GW, Headley J, Skowsky R. Scleredema diabeticorum: a common and distinct cutaneous manifestation of diabetes mellitus. Diabetes Care. 1983;6(2):189–92.

    Article  PubMed  CAS  Google Scholar 

  17. Wright RA, Bernie H. Scleredema adultorum of Buschke with upper esophageal involvement. Am J Gastroenterol. 1982;77(1):9–11.

    PubMed  CAS  Google Scholar 

  18. Dinneen AM, Dicken CH. Scleromyxedema. J Am Acad Dermatol. 1995;33(1):37–43.

    Article  PubMed  CAS  Google Scholar 

  19. Blum M, Wigley FM, Hummers LK. Scleromyxedema: a case series highlighting long-term outcomes of treatment with intravenous immunoglobulin (IVIG). Medicine (Baltimore). 2008;87(1):10–20.

    Article  Google Scholar 

  20. Berger JR, Dobbs MR, Terhune MH, Maragos WF. The neurologic complications of scleromyxedema. Medicine (Baltimore). 2001;80(5):313–9.

    Article  CAS  Google Scholar 

  21. Webster GF, Matsuoka LY, Burchmore D. The association of potentially lethal neurologic syndromes with scleromyxedema (papular mucinosis). J Am Acad Dermatol. 1993;28(1):105–8.

    Article  PubMed  CAS  Google Scholar 

  22. Godby A, Bergstresser PR, Chaker B, Pandya AG. Fatal scleromyxedema: report of a case and review of the literature. J Am Acad Dermatol. 1998;38(2 Pt 2):289–94.

    Article  PubMed  CAS  Google Scholar 

  23. Shulman LE. Diffuse fasciitis with eosinophilia: a new syndrome? Trans Assoc Am Physicians. 1975;88:70–86.

    PubMed  CAS  Google Scholar 

  24. Lakhanpal S, Ginsburg WW, Michet CJ, Doyle JA, Moore SB. Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases. Semin Arthritis Rheum. 1988;17(4):221–31.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Laura K. Hummers MD, ScM .

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Hummers, L.K. (2012). Scleroderma Mimics. In: Varga, J., Denton, C., Wigley, F. (eds) Scleroderma. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-5774-0_11

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  • DOI: https://doi.org/10.1007/978-1-4419-5774-0_11

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