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Intramyocardial Stem Cell Transplantation Without Tissue Engineered Constructs: The Current Clinical Situation

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Myocardial Tissue Engineering

Part of the book series: Studies in Mechanobiology, Tissue Engineering and Biomaterials ((SMTEB,volume 6))

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Abstract

After promising preclinical results, the surgical treatment of chronic ischemic heart disease patients with bone marrow stem cells has been successfully introduced within the last decade in the context of clinical studies and therapy trials. Combining intramyocardial bone marrow stem cell injection with established revascularisation procedures such as bypass surgery seems to offer additional functional benefits compared to standard therapy strategies alone. However, although the safety of intramyocardial stem cell therapy could be demonstrated, the clinical evidence obtained so far is heterogeneous and completion of ongoing Phase III trails is mandatory for conclusive evaluation regarding functional advantages offered by this new therapeutic tool in the cardiac surgeon’s hand. Besides ischemic heart disease also other pathologies—e.g. non-ischemic cardiomyopathy—might form indications for cardiac stem cell therapy, yet further clinical as well as preclinical evidence need to be obtained before adequate therapy strategies might be designed. Delivery and retention of adult stem cells remain limiting factors for treatment.

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  1. Department of Cardiac Surgery, University of Rostock, Schillingallee 35, 18057, Rostock, Germany

    Peter Donndorf & Gustav Steinhoff

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  1. Peter Donndorf
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  2. Gustav Steinhoff
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Correspondence to Peter Donndorf .

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  1. University of Erlangen-Nuremberg, Department of Materials Science and Engi, Institute of Biomaterials, Erlangen, 91058, Germany

    Aldo R. Boccaccini

  2. South Kensington Campus, Imperial College London, London, SW7 2AZ, United Kingdom

    Sian E. Harding

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Donndorf, P., Steinhoff, G. (2010). Intramyocardial Stem Cell Transplantation Without Tissue Engineered Constructs: The Current Clinical Situation. In: Boccaccini, A., Harding, S. (eds) Myocardial Tissue Engineering. Studies in Mechanobiology, Tissue Engineering and Biomaterials, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/8415_2010_45

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