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NPY as a pleiotropic growth factor

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The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer

Part of the book series: Progress in Inflammation Research ((PIR))

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Summary

With the discovery of NPY’s growth-regulatory effects, emerges a new role for the peptide in regulating cardiovascular, neuronal and immune functions. NPY is involved in angiogenesis, vascular remodeling, proliferation of neuronal cells, and regulation of immune responses. Its actions are cell- and receptor-specific and regulated by the proteolytic activity of DPPIV. Thus, the elucidation of the mechanisms underlying NPY actions can contribute to the development of new therapeutic strategies in the treatment of various disorders, including angiogenesis-related diseases, atherosclerosis, cancer and neuronal degeneration. The growing number of selective receptor agonists and antagonists could potentially become excellent tools to target the NPY system and clinically useful drugs. However, due to the pleiotropic activities of the peptide, the therapy would have to be carefully tailored to the type of the disease, with careful consideration given to the possible side effects.

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Authors and Affiliations

  1. Department of Physiology and Biophysics, Georgetown University School of Medicine, 3900 Reservoir Rd, NW Basic Science Building, Washington, DC, 20057, USA

    Joanna Kitlinska, Lydia E. Kuo & Jennifer Pons

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  1. Joanna Kitlinska
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  2. Lydia E. Kuo
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  3. Jennifer Pons
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Editors and Affiliations

  1. Department of Physiology and Biophysics, Georgetown University Medical Center, 3900 Reservoir Rd., NW, Washington, DC, 20057, USA

    Zofia Zukowska

  2. Wyeth Research, Building A3153 500 Arcola Rd, Collegeville, PA, 19426, USA

    Giora Z. Feuerstein

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© 2005 Birkhäuser Verlag Basel/Switzerland

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Kitlinska, J., Kuo, L.E., Pons, J. (2005). NPY as a pleiotropic growth factor. In: Zukowska, Z., Feuerstein, G.Z. (eds) The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7427-6_12

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