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Electrospun Nanofibrous Scaffolds-Current Status and Prospects in Drug Delivery

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Biomedical Applications of Polymeric Nanofibers

Part of the book series: Advances in Polymer Science ((POLYMER,volume 246))

Abstract

Controlled delivery systems are used to improve therapeutic efficacy and safety of drugs by delivering them over a period of treatment to the site of action at a rate dictated by the need of the physiological environment. A wide variety of polymeric materials, either biodegradable or non-biodegradable but biocompatible, can be used as delivery matrices. Recently, nanofibrous scaffolds, such as the systems fabricated by electrospinning or electrospraying, have been used in the field of biomedical engineering as wound dressings, scaffolds for tissue engineering, and drug delivery systems. The electrospun nanofibrous scaffolds can be used as carriers for various types of drugs, genes, and growth factors, whereby the release profile can be finely controlled by modulation of the scaffold’s morphology, porosity, and composition. The main advantage of this system is that it offers site-specific delivery of any number of therapeutics from the scaffold into the body. The aim of this chapter is to review the recent advances on electrospun nanofibrous scaffolds based on biodegradable and biocompatible polymers for controlled drug and biomolecule delivery applications. The use of electrospun scaffolds as drug carriers is promising for future biomedical applications, particularly in the prevention of post-surgical adhesions and infections, for postoperative local chemotherapy, and for bone and skin tissue engineering.

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Acknowledgments

One of the authors, R. Jayakumar, is grateful to SERC Division, Department of Science and Technology (DST), India, for providing funding under the scheme of “Fast Track Scheme for Young Investigators” (Ref. No. SR/FT/CS-005/2008). The author R. Jayakumar is also thankful to the Department of Biotechnology (DBT), Government of India for providing financial support to carry out research work under the Bioengineering Program (Ref. No. BT/PR13885/MED/32/145/2010). S.V. Nair is also grateful to DST, India, which partially supported this work under the Nanoscience and Nanotechnology Initiative program monitored by C.N.R. Rao.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Engineering and Technology, SRM University, Kattankulathur, 603 203, India

    M. Prabaharan

  2. Amrita for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Viswa Vidyapeetham University, Kochi, 682 041, India

    R. Jayakumar & S. V. Nair

Authors
  1. M. Prabaharan
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  2. R. Jayakumar
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  3. S. V. Nair
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Correspondence to M. Prabaharan .

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Editors and Affiliations

  1. Nanosciences and Molecular Medicine, Amrita Institute of, Amrita Center for, Cochin, 682041, India

    Rangasamy Jayakumar

  2. Nanosciences and Molecular Medicine, Amrita Institute of, Amrita Center for, Cochin, 682041, India

    Shantikumar Nair

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Prabaharan, M., Jayakumar, R., Nair, S.V. (2011). Electrospun Nanofibrous Scaffolds-Current Status and Prospects in Drug Delivery. In: Jayakumar, R., Nair, S. (eds) Biomedical Applications of Polymeric Nanofibers. Advances in Polymer Science, vol 246. Springer, Berlin, Heidelberg. https://doi.org/10.1007/12_2011_125

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