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Effects of intraarticular 32P colloid in the treatment of hemophilic synovitis of the knee

A short term clinical study

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Abstract

Background: Chronic synovitis is a consequence of recurrent intraarticular hemorrhage in patients with hemophilia. Eventually, synovitis leads to degeneration of the articular cartilage, with serious consequences that impact the quality-of-life in hemophiliacs. The aim of our study was to investigate the short term clinical effects of intraarticular injection of the radionuclide preparation 32P colloid (32P-labelled colloidal chromic phosphate suspension) on recurrent intraarticular hemorrhages in patients with hemophilic synovitis of the knee.

Materials and Methods: Patients who met the inclusion criteria (n = 22) were enrolled in an open-label study between October 2011 and September 2012. 32P colloid was injected into the knee joint and patients were followed up over 6 months after treatment. Hemorrhage frequency, visual analog scale pain score, hospital for special surgery knee score, knee circumference, upper knee circumference, knee diameter, and knee range of motion (ROM) were compared before and after treatment with intraarticular 32P colloid injection.

Results: In 24 knees evaluated in 22 participating patients, there was a significant reduction in the number of hemorrhages after 32P colloid treatment, along with significant pain relief. However, there were no statistically significant changes in the degree of joint swelling, degree of muscle atrophy and knee ROM between the pre and post treatment evaluations.

Conclusion: The frequency of joint hemorrhage in patients with hemophilic knee synovitis can be significantly reduced and local symptoms can be improved in the short term by intraarticular injection of 32P colloid.

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Authors and Affiliations

  1. Department of Orthopaedics, Shandong Qianfoshan Hospital, Affiliated to Shandong University, No. 16766, **gshi Road, **an, Shandong, 250014, P.R. China

    Wen-Qiang Zhang, Zhen Yuan, Ye-Teng He, Hu Zhang &  Ming Zhang

  2. Blood Component Department, Blood Center of Shandong Province, **an, Shandong, P.R. China

    Shao-Qin Han

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  1. Wen-Qiang Zhang
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  2. Shao-Qin Han
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  3. Zhen Yuan
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  4. Ye-Teng He
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  5. Hu Zhang
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  6. Ming Zhang
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Correspondence to Ming Zhang.

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This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Zhang, WQ., Han, SQ., Yuan, Z. et al. Effects of intraarticular 32P colloid in the treatment of hemophilic synovitis of the knee. IJOO 50, 55–58 (2016). https://doi.org/10.4103/0019-5413.173507

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  • DOI: https://doi.org/10.4103/0019-5413.173507

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