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Review: Micro- and nanostructured surface engineering for biomedical applications

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Abstract

The engineering of well-defined micro- and nanoscaled surface topographies on biomedical metals and polymeric materials has been explored as a strategy to control biological responses. In this review, the ability of surface features engineered by a variety of methods to promote or reduce protein, blood, and bacterial adhesion is discussed independent of surface chemistry. The interaction of proteins with surface topography is fundamentally important and influences the conformation, the types of protein, as well as the overall amount of protein adhesion, which in many instances is increased over the associated increase in surface area. The use of superhydrophobic surface features is discussed as a manner to engineer antifouling surfaces with protein, blood, and bacterial resistance.

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Authors and Affiliations

  1. Institute of Materials Research and Engineering, Agency for Science, Technology and Research (A*STAR), Research Link, Singapore, 117602

    Emma Luong-Van, Isabel Rodriguez & Hong Yee Low

  2. Advanced Technologies and Regenerative Medicine, LLC, A Johnson and Johnson Company, Somerville, New Jersey, 08876, USA

    Noha Elmouelhi, Bruce Lowenhaupt, Sriram Natarajan, Chee Tiong Lim, Rita Prajapati, Murty Vyakarnam & Kevin Cooper

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  1. Emma Luong-Van
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  2. Isabel Rodriguez
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Luong-Van, E., Rodriguez, I., Low, H.Y. et al. Review: Micro- and nanostructured surface engineering for biomedical applications. Journal of Materials Research 28, 165–174 (2013). https://doi.org/10.1557/jmr.2012.398

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