Abstract
The basic objective of this work was to study the effect of model cationic drug metformin HCl on swelling and erosion and, in turn, the release of KCl and drug itself, from the κ-carrageenan matrices. Water uptake by the matrix up to 2 hours was found to increase with KCl concentration from the plain matrix. Erosion was not affected by concentration of KCl. Incorporation of drug favors water uptake, but in presence of KCl it was found to be reduced. Drugcontaining matrices have shown higher release of KCl as compared with plain batches. Drug release was retarded as KCl concentration increased up to 5%, above which the reduced cohesivity of the matrix caused increase in drug release.
Similar content being viewed by others
References
Brazel CS, Peppas NA. Modelling of drug release from swellable polymers. Eur J Pharm Biopharm. 2000;49:47–58.
Guo JH, Skinner GW, Harcum WW, Barnum PE. Pharmaceutical application of naturally occurring water-soluble polymers. PSTT. 1998;1:254–261.
Gupta VK, Hariharan M, Wheately TA, Price JC. Controlled-release tablets from carrageenans: effect of formulation, storage and dissolution factors. Eur J Pharm Biopharm. 2001;51:241–248.
Peppas NA. Analysis of Fickian and non-Fickian drug release from polymers. Pharm Acta Helv. 1985;60:110–111.
FMC: Marine Colloids Carrageenan, General Technology. Philadelphia, PA: FMC Corporation; 1993.
Hariharan M, Wheatley TA, Price JC. Controlled-release tablet matrices from carrageenans: compression and dissolution studies. Pharm Dev Technol. 1997;2:383–393.
Masaaki S, Chikanori Y, Kazuhiro H, et al. Structural change of κ-carrageenan gel near sol-gel transition point. Physica B. 1998;243:999–1001.
van de Velde F, Peppelman A, Rollema HS, Tromp RH. On the structure of κτ-hybrid carrageenans. Carbohydr Res. 2001;331:271–283.
Yuguchi Y, Thuy TTT, Urakawa H, Kajiwara K. Structural characteristic of carrageenan gels: temperature and concentration dependence. Journal. 2002;16:515–522.
Picker KM. Carrageenans used for tabletting and controlled release. Proceedings of the 2nd World Meeting. May 25–28, 1998; Paris, France.
Picker KM. Matrix tablets of carrageenans. I. A compaction study. Drug Dev Ind Pharm. 1999;25:329–337.
Jovetic S, Beeftink HH, Tramper J, Marinelli F. Diffusion of (de)acylated antibiotic A40926 in alginate and carrageenan beads with or without cells and/or soybean meal. Enzyme and Microbiology Technology. 2001;28:510–514.
Sipahigil O, Dortune B. Preparation and in vitro evaluation of verapamil HCl and ibuprofen containing carrageenan beads. Int J Pharm. 2001;228:119–128.
Hoffinan AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev. 2002;54:3–12.
Rochas C, Rinaudo M. Activity coefficient of counterions and conformation in κ-carrageenan system. Biopolymers. 1980;19:1675–1687.
Morris ER, Rees DA, Norto IT, Goodall DM. Cation-specific aggregation of carrageenan helices: domain model of polymer gel structure. J Mol Biol. 1980;138:349–362.
Schmidt AG, Wartewigand S, Picker KM. Potential of carrageenan to protect drugs from polymorphic transformation. Eur J Pharm Biopharm. 2003;56:101–110.
Picker KM. Matrix tablets of Carrageenans. II. Release behavior and effect of added cations. Drug Dev Ind Pharm. 1999;25:339–346.
Sjöberg H, Persson S, Caram-Lelham N. How interactions between drugs and agarose-carrageenan hydrogels influence the simultaneous transport of drugs. J Control Release. 1999;59:391–400.
Roy DS, Rohera BD. Comparative evaluation of rate of hydration and matrix erosion of HEC and HPC and study of drug release from their matrices. Eur J Pharm Sci. 2002;16:193–199.
Vergnaud JM. Liquid transport controlled release process in polymeric materials: applications to oral dosage forms. Int J Pharm. 1993;90:89–94.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Naim, S., Samuel, B., Chauhan, B. et al. Effect of potassium chloride and cationic drug on swelling, erosion and release from κ-carrageenan matrices. AAPS PharmSciTech 5, 25 (2004). https://doi.org/10.1208/pt050225
Received:
Accepted:
DOI: https://doi.org/10.1208/pt050225