Abstract
A prospective randomized double blind trial was carried out to test whether prenatal glucocorticoids could reduce risk of RDS in prematurely born infants. Mothers ( < 33 weeks gestation) with premature labor or with premature rupture of membranes, were treated with dexamethasone-PO4 (4mg IM Q8H × 6) or saline (lml IM Q8H × 6). Risk factors for RDS or infection were not different in steroid and placebo groups. Prophylactic antibiotics were not used.
In this study the duration of rupture of membranes and the duration of the interval from entry into study to delivery did not affect risk of RDS. We conclude that glucocorticoids 1) are effective in lowering incidence and severity of RDS, and 2) may be associated with increased risk of infection (usually endometritis).
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Taeusch, H., Frigoletto, F., Kitzmiller, J. et al. 1031 RISK OF RESPIRATORY DISTRESS SYNDROME AND MATERNAL INFECTION AFTER PRENATAL DEXAMETHASONE TREATMENT. Pediatr Res 12 (Suppl 4), 535 (1978). https://doi.org/10.1203/00006450-197804001-01037
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DOI: https://doi.org/10.1203/00006450-197804001-01037
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