Abstract
Experimental Coxsackie B-3 virus infection in newborn mice was utilized to examine the protective role of circulating antibodies. Subcutaneous administration of specific antiviral antibodies to the infected mice resulted in a significant protection against the lethal infection of Coxsackie B-3 virus.
Exogenous administration of antibodies to pregnant mothers also resulted in an enhanced resistance to Coxsackie B-3 infection in the offsprings. These antibodies are transferred primarily through the placenta. However, intestinal absorption of the antibodies through breast milk may also provide some protection.
These data suggest that antibody-mediated immunity play a significant role in resistance against Coxsackie B-3 virus infection in the newborn.
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Cho, C., Feng, F. & McCarthy, V. 758 THE ROLE OF MATERNALLY TRANSFERRED ANTIBODIES IN I THE RESISTANCE OF NEWBORN MICE AGAINST COXSACKIE B-3 VIRUS INFECTION. Pediatr Res 12 (Suppl 4), 490 (1978). https://doi.org/10.1203/00006450-197804001-00763
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DOI: https://doi.org/10.1203/00006450-197804001-00763
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