Abstract
A case of acute undifferentiated leukemia in an 8-year-old child is reported. The presenting feature of the disease was a marked peripheral eosinophilia (80%) with immature and somewhat atypical eosinophils. The bone marrow showed prevalence of large blast cells with scarce basophilic cytoplasm and one or more nucleoli. The rate of eosinophils was increased. The presence of parasitic infections or allergic diseases was excluded. Two short term remissions were obtained. No eosinophilia was observed during the subsequent relapses. Death ensued after 17 months.
Differential diagnosis with the eosinophilic leukemia, the hypereosinophilic syndromes and the eosinophilic leukemoid reaction is done. The significance of marked eosinophilia in acute leukemia is discussed, mainly aa an initial response to some still poorly defined antigenic stimulus of the leukemic cells. Its relationship to the so called tumor associated eosinophilic factor is aloo taken into account.
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Rasore-Quartino, A., Moscatelli, P. ACUTE UNDIFFERENTIATED LEUKEMIA WITH EOSINOPHILIA IN A CHILD. Pediatr Res 12, 71 (1978). https://doi.org/10.1203/00006450-197801000-00065
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DOI: https://doi.org/10.1203/00006450-197801000-00065
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