Abstract
Background
B7-H3 has been implicated in clinical pathological features and prognosis across various cancer types, suggesting its potential as a cancer biomarker. Nevertheless, consensus remains elusive regarding its clinical-pathological and prognostic significance in bladder cancer. To address this gap, we conducted a systematic review and meta-analysis.
Methods
We systematically searched PubMed, Embase, Web of Science, Cochrane, and CNKI databases from their inception up to October 6, 2022. We evaluated the literature’s quality using the Newcastle-Ottawa Scale. We performed meta-analysis using Review Manager 5.3 and STATA 12.0, synthesizing data and calculating odds ratios (ORs) or hazard ratios (HRs) with corresponding 95% confidence intervals (CIs).
Results
After applying eligibility criteria and conducting assessments, we included data from 8 studies, encompassing 1622 bladder cancer patients. Bladder tumor tissues exhibited significantly elevated B7-H3 protein expression compared to normal bladder tissues. Elevated B7-H3 expression was notably associated with patient age, tumor infiltration, and recurrence in bladder cancer. However, no significant correlations were observed with other clinical characteristics. Our pooled HR analysis indicated no significant association between B7-H3 expression and overall survival in bladder cancer patients.
Conclusion
Our meta-analysis unveils the complex role of B7-H3 in bladder cancer progression. It appears to be directly involved in tumor infiltration and recurrence but cannot definitively serve as a prognostic biomarker for bladder cancer. To validate these findings, further well-designed studies, encompassing larger sample sizes and diverse racial backgrounds, are warranted.
PROSPERO registration
No. CRD42022364688.
Similar content being viewed by others
Introduction
Bladder cancer (BC) is a common cancer of the urinary tract, with an estimated 573,278 new cases and 212,536 deaths annually worldwide [1]. The disease is clinically classified into nonmuscle invasive bladder cancer (NMIBC)(Ta/T1) and muscle-invasive bladder cancer (MIBC)(T2-T4), based on different clinical progressions and prognoses. Despite advancements in current therapeutic methods, including surgery, radiation therapy, and chemotherapy, the 5-year overall survival (OS) rate remains unsatisfactory, particularly for advanced bladder cancer [2,3,4]. Therefore, finding a novel biomarker as an effective therapeutic target to improve the prognosis of bladder cancer patients is crucial.
Bladder cancer (BC) has been extensively studied for prognostic markers [5,6,7,8,9]. CTCs have emerged as potential prognostic markers in various cancers [10,8, 21]. Given these limitations and uncertainties, there is a need for improved prognostic biomarkers in BC to enhance clinical management and treatment decisions.
B7-H3 (CD276) belongs to the B7 superfamily of molecules and shows potential as a promising target for cancer treatment. The expression of the B7-H3 protein has been observed in various tumor tissues, including non-small cell lung cancer (NSCLC) and prostate cancer, and it is closely associated with tumor progression, metastasis, recurrence, and other adverse clinical features [22,23,55,56,57,58]. These results have paved the way for clinical trials focusing on B7-H3 targeting. In the context of bladder cancer, Ma et al. [59] demonstrated an increase in CD69 expression on activated T cells (ATC) when treated with an anti-CD3-B7-H3 bispecific antibody (B7-H3Bi-Ab). CD69 is considered an early activation marker for T cells. B7-H3Bi-Ab-ATC have the capability to eliminate B7-H3-positive bladder cancer cells through the CD3-B7-H3 bridge mechanism, exhibiting significant cytotoxic activity against human bladder cancer cells. These findings suggest that B7-H3Bi-Ab enhances the killing potential of ATC against bladder cancer cells, offering a promising novel approach for the treatment of bladder cancer.
Although efforts have been made, our study still has some limitations. Firstly, the main ethnic populations were European and Asian, and African representation was insufficient. Secondly, the pooled analyses of the relationships between B7-H3 expression and prognosis and patient clinicopathological features, such as tumor grade and T stage, were based on a relatively small number of studies. More research is needed to validate these results and obtain more reliable conclusions. Thirdly, the included studies used different criteria for judging the positive or negative expression of B7-H3, leading to some heterogeneity in the meta-analysis. This could affect the overall accuracy of the results. Fourthly, we did not include unpublished articles and conference abstracts in the meta-analysis due to insufficient information, which may introduce selection bias and potentially miss relevant data. Fifthly, the sample size of our meta-analysis was relatively small, which may limit the statistical power to detect certain associations, especially in the analysis of overall survival. Lastly, because some included articles did not report detailed survival data, we had to rely on the Kaplan-Meier curve for survival analysis, which might lead to potential overestimation or underestimation of actual survival data. To address these limitations, future research should focus on conducting well-designed clinical randomized controlled studies with larger sample sizes that encompass diverse racial backgrounds to provide more robust and comprehensive insights into the relationship between B7-H3 expression and bladder cancer.
Conclusion
In conclusion, our study confirms that B7-H3 is overexpressed in bladder cancer (BC), and its expression is closely related to tumor invasion and recurrence in BC. Furthermore, B7-H3 expression has shown no association with the survival of bladder cancer patients, suggesting that B7-H3 may play multiple roles in the pathophysiology of bladder cancer. To address the limitations of the current meta-analysis, it is imperative that future studies with larger sample sizes and standardized methodologies be conducted. Additionally, investigating the underlying mechanisms by which B7-H3 influences tumor progression holds the potential to contribute to the development of innovative treatment strategies for bladder cancer.
Data availability
Data come from published literature.
References
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71(3):209–49. https://doi.org/10.3322/caac.21660.
Kubota Y, Nakaigawa N. Essential content of evidence-based clinical practice guidelines for bladder cancer: the Japanese Urological Association 2015 update. Int J Urology: Official J Japanese Urol Association. 2016;23(8):640–5. https://doi.org/10.1111/iju.13141.
Clark PE, Spiess PE, Agarwal N, Bangs R, Boorjian SA, Buyyounouski MK, Efstathiou JA, Flaig TW, Friedlander T, Greenberg RE, et al. NCCN guidelines insights: bladder Cancer, Version 2.2016. J Natl Compr Cancer Network: JNCCN. 2016;14(10):1213–24. https://doi.org/10.6004/jnccn.2016.0131.
Babjuk M, Böhle A, Burger M, Capoun O, Cohen D, Compérat EM, Hernández V, Kaasinen E, Palou J, Rouprêt M, et al. EAU guidelines on Non-muscle-invasive Urothelial Carcinoma of the bladder: Update 2016. Eur Urol. 2017;71(3):447–61. https://doi.org/10.1016/j.eururo.2016.05.041.
Wang G, Black PC, Goebell PJ, Ji L, Cordon-Cardo C, Schmitz-Dräger B, Hawes D, Czerniak B, Minner S, Sauter G, et al. Prognostic markers in pT3 bladder cancer: a study from the international bladder cancer tissue microarray project. Urol Oncol. 2021;39(5):301. https://doi.org/10.1016/j.urolonc.2021.01.021.
Fouad H, Salem H, Ellakwa DE, Abdel-Hamid M. MMP-2 and MMP-9 as prognostic markers for the early detection of urinary bladder cancer. J Biochem Mol Toxicol. 2019;33(4):e22275. https://doi.org/10.1002/jbt.22275.
Awadalla A, Abol-Enein H, Hamam ET, Ahmed AE, Khirallah SM, El-Assmy A, Mostafa SA, Babalghith AO, Ali M, Abdel-Rahim M, et al. Identification of epigenetic interactions between miRNA and gene expression as potential prognostic markers in bladder Cancer. Genes. 2022;13(9). https://doi.org/10.3390/genes13091629.
Breyer J, Wirtz RM, Otto W, Laible M, Schlombs K, Erben P, Kriegmair MC, Stoehr R, Eidt S, Denzinger S, et al. Predictive value of molecular subty** in NMIBC by RT-qPCR of ERBB2, ESR1, PGR and MKI67 from Formalin fixed TUR biopsies. Oncotarget. 2017;8(40):67684–95. https://doi.org/10.18632/oncotarget.18804.
Azevedo R, Soares J, Peixoto A, Cotton S, Lima L, Santos LL, Ferreira JA. Circulating tumor cells in bladder cancer: emerging technologies and clinical implications foreseeing precision oncology. Urol Oncol. 2018;36(5):221–36. https://doi.org/10.1016/j.urolonc.2018.02.004.
Murlidhar V, Reddy RM, Fouladdel S, Zhao L, Ishikawa MK, Grabauskiene S, Zhang Z, Lin J, Chang AC, Carrott P, et al. Poor prognosis indicated by venous circulating tumor cell clusters in early-stage lung cancers. Cancer Res. 2017;77(18):5194–206. https://doi.org/10.1158/0008-5472.Can-16-2072.
Yu JJ, **ao W, Dong SL, Liang HF, Zhang ZW, Zhang BX, Huang ZY, Chen YF, Zhang WG, Luo HP, et al. Effect of surgical liver resection on circulating tumor cells in patients with hepatocellular carcinoma. BMC Cancer. 2018;18(1):835. https://doi.org/10.1186/s12885-018-4744-4.
Jansson S, Bendahl PO, Larsson AM, Aaltonen KE, Rydén L. Prognostic impact of circulating tumor cell apoptosis and clusters in serial blood samples from patients with metastatic breast cancer in a prospective observational cohort. BMC Cancer. 2016;16:433. https://doi.org/10.1186/s12885-016-2406-y.
Crocetto F, Cimmino A, Ferro M, Terracciano D. Circulating tumor cells in bladder cancer: a new horizon of liquid biopsy for precision medicine. J Basic Clin Physiol Pharmacol. 2022;33(5):525–7. https://doi.org/10.1515/jbcpp-2021-0233.
van Oers JM, Zwarthoff EC, Rehman I, Azzouzi AR, Cussenot O, Meuth M, Hamdy FC, Catto JW. FGFR3 mutations indicate better survival in invasive upper urinary tract and bladder tumours. Eur Urol. 2009;55(3):650–7. https://doi.org/10.1016/j.eururo.2008.06.013.
van Rhijn BW, van der Kwast TH, Liu L, Fleshner NE, Bostrom PJ, Vis AN, Alkhateeb SS, Bangma CH, Jewett MA, Zwarthoff EC, et al. The FGFR3 mutation is related to favorable pT1 bladder cancer. J Urol. 2012;187(1):310–4. https://doi.org/10.1016/j.juro.2011.09.008.
Tabernero J, Bahleda R, Dienstmann R, Infante JR, Mita A, Italiano A, Calvo E, Moreno V, Adamo B, Gazzah A, et al. Phase I dose-escalation study of JNJ-42756493, an oral pan-fibroblast growth factor receptor inhibitor, in patients with Advanced Solid tumors. J Clin Oncology: Official J Am Soc Clin Oncol. 2015;33(30):3401–8. https://doi.org/10.1200/jco.2014.60.7341.
Schuler M, Cho BC, Sayehli CM, Navarro A, Soo RA, Richly H, Cassier PA, Tai D, Penel N, Nogova L, et al. Rogaratinib in patients with advanced cancers selected by FGFR mRNA expression: a phase 1 dose-escalation and dose-expansion study. Lancet Oncol. 2019;20(10):1454–66. https://doi.org/10.1016/s1470-2045(19)30412-7.
Necchi A, Castellano DE, Mellado B, Pang S, Urun Y, Park SH, Vaishampayan UN, Currie G, Abella-Dominicis E, Pal SK. Fierce-21: phase II study of vofatmab (B-701), a selective inhibitor of FGFR3, as salvage therapy in metastatic urothelial carcinoma (mUC). J Clin Oncol. 2019;37(7). https://doi.org/10.1200/JCO.2019.37.7_suppl.409.
Kriegmair MC, Wirtz RM, Worst TS, Breyer J, Ritter M, Keck B, Boehmer C, Otto W, Eckstein M, Weis CA, et al. Prognostic value of molecular breast Cancer subtypes based on Her2, ESR1, PGR and Ki67 mRNA-Expression in muscle invasive bladder Cancer. Translational Oncol. 2018;11(2):467–76. https://doi.org/10.1016/j.tranon.2018.02.001.
Nedjadi T, Al-Maghrabi J, Assidi M, Dallol A, Al-Kattabi H, Chaudhary A, Al-Sayyad A, Al-Ammari A, Abuzenadah A, Buhmeida A, et al. Prognostic value of HER2 status in bladder transitional cell carcinoma revealed by both IHC and BDISH techniques. BMC Cancer. 2016;16:653. https://doi.org/10.1186/s12885-016-2703-5.
Rodriguez Pena MDC, Chaux A, Eich ML, Tregnago AC, Taheri D, Borhan W, Sharma R, Rezaei MK, Netto GJ. Immunohistochemical assessment of basal and luminal markers in non-muscle invasive urothelial carcinoma of bladder. Virchows Archiv: Int J Pathol. 2019;475(3):349–56. https://doi.org/10.1007/s00428-019-02618-5.
Tekle C, Nygren MK, Chen YW, Dybsjord I, Nesland JM, Maelandsmo GM, Fodstad O. B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes. Int J Cancer. 2012;130(10):2282–90. https://doi.org/10.1002/ijc.26238.
Picarda E, Ohaegbulam KC, Zang X. Molecular pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy. Clin cancer Research: Official J Am Association Cancer Res. 2016;22(14):3425–31. https://doi.org/10.1158/1078-0432.Ccr-15-2428.
Mao Y, Li W, Chen K, **e Y, Liu Q, Yao M, Duan W, Zhou X, Liang R, Tao M. B7-H1 and B7-H3 are independent predictors of poor prognosis in patients with non-small cell lung cancer. Oncotarget. 2015;6(5):3452–61. https://doi.org/10.18632/oncotarget.3097.
Ma J, Ma P, Zhao C, Xue X, Han H, Liu C, Tao H, **u W, Cai J, Zhang M. B7-H3 as a promising target for cytotoxicity T cell in human cancer therapy. Oncotarget. 2016;7(20):29480–91. https://doi.org/10.18632/oncotarget.8784.
Kang FB, Wang L, Jia HC, Li D, Li HJ, Zhang YG, Sun DX. B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway. Cancer Cell Int. 2015;15:45. https://doi.org/10.1186/s12935-015-0195-z.
Benzon B, Zhao SG, Haffner MC, Takhar M, Erho N, Yousefi K, Hurley P, Bishop JL, Tosoian J, Ghabili K, et al. Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis. Prostate Cancer Prostatic Dis. 2017;20(1):28–35. https://doi.org/10.1038/pcan.2016.49.
Wang S, Zhang X, Ning H, Dong S, Wang G, Sun R. B7 homolog 3 induces lung metastasis of breast cancer through Raf/MEK/ERK axis. Breast Cancer Res Treat. 2022;193(2):405–16. https://doi.org/10.1007/s10549-022-06520-8.
Shao X, Zhan S, Quan Q, Shen Y, Chen S, Zhang X, Li R, Liu M, Cao L. Clinical significance of B7-H3 and HER2 co-expression and therapeutic value of combination treatment in gastric cancer. Int Immunopharmacol. 2022;110:108988. https://doi.org/10.1016/j.intimp.2022.108988.
Lee JH, Kim YJ, Ryu HW, Shin SW, Kim EJ, Shin SH, Park JY, Kim SY, Hwang CS, Na JY, et al. B7-H3 expression is associated with high PD-L1 expression in clear cell renal cell carcinoma and predicts poor prognosis. Diagn Pathol. 2023;18(1):36. https://doi.org/10.1186/s13000-023-01320-0.
Stang A. Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol. 2010;25(9):603–5. https://doi.org/10.1007/s10654-010-9491-z.
Zhili X, Ling w, Jianhua T, Changchun L, 满宏伟. **鹏飞, 单亚楠, 单保恩: the association and prognostic significance of B7-H3 with CD68 + tumor-associated macrophages in urothelial cell carcinoma. Chin J Urol. 2016;37(06):470–4. https://doi.org/10.3760/cma.j.issn.1000-6702.2016.06.019. (in Chinese).
Xylinas E, Robinson BD, Kluth LA, Volkmer BG, Hautmann R, Küfer R, Zerbib M, Kwon E, Thompson RH, Boorjian SA, et al. Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder. Eur J Surg Oncol. 2014;40(1):121–7. https://doi.org/10.1016/j.ejso.2013.08.023.
Xu Z-L, Zhang Y, Wang L, Li F, Man H-W, Li P-F, Shan B-E. B7-H3 promotes malignant progression of muscle-invasive bladder cancer. Oncol Rep. 2018;40(5):2722–33. https://doi.org/10.3892/or.2018.6655.
Xu Z, Wang L, Tian J, Man H, Li P, Shan B. High expression of B7-H3 and CD163 in cancer tissues indicates malignant clinicopathological status and poor prognosis of patients with urothelial cell carcinoma of the bladder. Oncol Lett. 2018;15(5):6519–26. https://doi.org/10.3892/ol.2018.8173.
Mahmoud AM, Frank I, Orme JJ, Lavoie RR, Thapa P, Costello BA, Cheville JC, Gupta S, Dong H, Lucien F. Evaluation of PD-L1 and B7-H3 expression as a predictor of response to adjuvant chemotherapy in bladder cancer. BMC Urol. 2022;22(1). https://doi.org/10.1186/s12894-022-01044-1.
Li Y, Guo G, Song J, Cai Z, Yang J, Chen Z, Wang Y, Huang Y, Gao Q. B7-H3 promotes the migration and invasion of human bladder cancer cells via the PI3K/Akt/STAT3 signaling pathway. J Cancer. 2017;8(5):816–24. https://doi.org/10.7150/jca.17759.
Boorjian SA, Sheinin Y, Crispen PL, Farmer SA, Lohse CM, Kuntz SM, Leibovich BC, Kwon ED, Frank I. T-cell coregulatory molecule expression in urothelial cell carcinoma: clinicopathologic correlations and association with survival. Clin Cancer Res. 2008;14(15):4800–8. https://doi.org/10.1158/1078-0432.Ccr-08-0731.
Azuma T, Sato Y, Ohno T, Azuma M, Kume H. Serum soluble B7-H3 is a prognostic marker for patients with non-muscle-invasive bladder cancer. PLoS ONE. 2020;15(12 December). https://doi.org/10.1371/journal.pone.0243379.
Kontos F, Michelakos T, Kurokawa T, Sadagopan A, Schwab JH, Ferrone CR, Ferrone S. B7-H3: an attractive target for antibody-based Immunotherapy. Clin cancer Research: Official J Am Association Cancer Res. 2021;27(5):1227–35. https://doi.org/10.1158/1078-0432.Ccr-20-2584.
Vigdorovich V, Ramagopal UA, Lázár-Molnár E, Sylvestre E, Lee JS, Hofmeyer KA, Zang X, Nathenson SG, Almo SC. Structure and T cell inhibition properties of B7 family member, B7-H3. Structure. 2013;21(5):707–17. https://doi.org/10.1016/j.str.2013.03.003.
Seaman S, Zhu Z, Saha S, Zhang XM, Yang MY, Hilton MB, Morris K, Szot C, Morris H, Swing DA, et al. Eradication of tumors through simultaneous ablation of CD276/B7-H3-Positive tumor cells and Tumor vasculature. Cancer Cell. 2017;31(4):501–515e508. https://doi.org/10.1016/j.ccell.2017.03.005.
Cong F, Yu H, Gao X. Expression of CD24 and B7-H3 in breast cancer and the clinical significance. Oncol Lett. 2017;14(6):7185–90. https://doi.org/10.3892/ol.2017.7142.
Yonesaka K, Haratani K, Takamura S, Sakai H, Kato R, Takegawa N, Takahama T, Tanaka K, Hayashi H, Takeda M, et al. B7-H3 negatively modulates CTL-Mediated Cancer Immunity. Clin cancer Research: Official J Am Association Cancer Res. 2018;24(11):2653–64. https://doi.org/10.1158/1078-0432.Ccr-17-2852.
Zang X, Sullivan PS, Soslow RA, Waitz R, Reuter VE, Wilton A, Thaler HT, Arul M, Slovin SF, Wei J, et al. Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas. Mod Pathol. 2010;23(8):1104–12. https://doi.org/10.1038/modpathol.2010.95.
Nunes-Xavier CE, Karlsen KF, Tekle C, Pedersen C, Øyjord T, Hongisto V, Nesland JM, Tan M, Sahlberg KK, Fodstad Ø. Decreased expression of B7-H3 reduces the glycolytic capacity and sensitizes breast cancer cells to AKT/mTOR inhibitors. Oncotarget. 2016;7(6):6891–901. https://doi.org/10.18632/oncotarget.6902.
Chen L, Chen J, Xu B, Wang Q, Zhou W, Zhang G, Sun J, Shi L, Pei H, Wu C, et al. B7-H3 expression associates with tumor invasion and patient’s poor survival in human esophageal cancer. Am J Translational Res. 2015;7(12):2646–60.
Sun J, Guo YD, Li XN, Zhang YQ, Gu L, Wu PP, Bai GH, **ao Y. B7-H3 expression in breast cancer and upregulation of VEGF through gene silence. OncoTargets Therapy. 2014;7:1979–86. https://doi.org/10.2147/ott.S63424.
Zhao X, Li DC, Zhu XG, Gan WJ, Li Z, **ong F, Zhang ZX, Zhang GB, Zhang XG, Zhao H. B7-H3 overexpression in pancreatic cancer promotes tumor progression. Int J Mol Med. 2013;31(2):283–91. https://doi.org/10.3892/ijmm.2012.1212.
Zhong C, Tao B, Chen Y, Guo Z, Yang X, Peng L, **a X, Chen L. B7-H3 regulates Glioma Growth and Cell Invasion through a JAK2/STAT3/Slug-Dependent signaling pathway. OncoTargets Therapy. 2020;13:2215–24. https://doi.org/10.2147/ott.S237841.
Zhao X, Zhang GB, Gan WJ, **ong F, Li Z, Zhao H, Zhu DM, Zhang B, Zhang XG, Li DC. Silencing of B7-H3 increases gemcitabine sensitivity by promoting apoptosis in pancreatic carcinoma. Oncol Lett. 2013;5(3):805–12. https://doi.org/10.3892/ol.2013.1118.
Ingebrigtsen VA, Boye K, Tekle C, Nesland JM, Flatmark K, Fodstad O. B7-H3 expression in colorectal cancer: nuclear localization strongly predicts poor outcome in colon cancer. Int J Cancer. 2012;131(11):2528–36. https://doi.org/10.1002/ijc.27566.
Crispen PL, Sheinin Y, Roth TJ, Lohse CM, Kuntz SM, Frigola X, Thompson RH, Boorjian SA, Dong H, Leibovich BC, et al. Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma. Clin cancer Research: Official J Am Association Cancer Res. 2008;14(16):5150–7. https://doi.org/10.1158/1078-0432.Ccr-08-0536.
Kang FB, Wang L, Li D, Zhang YG, Sun DX. Hepatocellular carcinomas promote tumor-associated macrophage M2-polarization via increased B7-H3 expression. Oncol Rep. 2015;33(1):274–82. https://doi.org/10.3892/or.2014.3587.
Lu H, Shi T, Wang M, Li X, Gu Y, Zhang X, Zhang G, Chen W. B7-H3 inhibits the IFN-γ-dependent cytotoxicity of Vγ9Vδ2 T cells against colon cancer cells. Oncoimmunology. 2020;9(1):1748991. https://doi.org/10.1080/2162402x.2020.1748991.
Loo D, Alderson RF, Chen FZ, Huang L, Zhang W, Gorlatov S, Burke S, Ciccarone V, Li H, Yang Y, et al. Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity. Clin cancer Research: Official J Am Association Cancer Res. 2012;18(14):3834–45. https://doi.org/10.1158/1078-0432.Ccr-12-0715.
Lee YH, Martin-Orozco N, Zheng P, Li J, Zhang P, Tan H, Park HJ, Jeong M, Chang SH, Kim BS, et al. Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function. Cell Res. 2017;27(8):1034–45. https://doi.org/10.1038/cr.2017.90.
Kasten BB, Arend RC, Katre AA, Kim H, Fan J, Ferrone S, Zinn KR, Buchsbaum DJ. B7-H3-targeted (212)pb radioimmunotherapy of ovarian cancer in preclinical models. Nucl Med Biol. 2017;47:23–30. https://doi.org/10.1016/j.nucmedbio.2017.01.003.
Ma W, Ma J, Ma P, Lei T, Zhao M, Zhang M. Targeting immunotherapy for bladder cancer using anti-CD3× B7-H3 bispecific antibody. Cancer Med. 2018;7(10):5167–77. https://doi.org/10.1002/cam4.1775.
Funding
This research was supported by the Taihu Talents Scheme of China (HB2020013).
Author information
Authors and Affiliations
Contributions
Conception/design: SHH, LY and SJF. Collection and assembly of data: SHH and GF. Data analysis and interpretation: SHH and LY. Article writing: SHH, GF, and SJF. Final approval of the article: all authors.
Corresponding author
Ethics declarations
Ethics approval and consent to participate
The study was not primary research involving humans or animals but was a secondary analysis of human subject data available in the public domain.
Consent for publication
Not applicable.
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
sun, H., Gao, F., Liu, Y. et al. Survival and clinicopathological significance of B7-H3 in bladder cancer: a systematic review and meta-analysis. BMC Urol 24, 57 (2024). https://doi.org/10.1186/s12894-024-01446-3
Received:
Accepted:
Published:
DOI: https://doi.org/10.1186/s12894-024-01446-3