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Structure of the Peritenons of the Paravertebral Tendons Treated with Hyaluronic Acid

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Abstract

The tendon sheaths (peritenons) of the paravertebral tendons of the tails of Wistar rats were studied using scanning electron microscopy. A phenomenological classification of the osteoid structures of the peritenons is given, with the identification of their persistent and permanent varieties. Sesamoid islets, needle-like and lamellar growths, and rudiments of osteons are classified as persistent. Persistent osteoid structures are well prepared for transformations aimed at strengthening the intracellular matrix under mechanical stress. Permanent osteoid structures are microgranules and faceted deposits of calcium phosphates involved in structural and mechanical processes and hetero- and homogeneous nucleation. Hyaluronate loosens the matrix of sesamoid islets, which increases the mobility of sesamoid globules and creates the prerequisites for their directed migration to areas of increased mechanical stress and foci of possible mineralization of extracellular substance, including fibrillar collagen. Hyaluronate sticks together granules and deposits of structured calcium phosphates and contributes to their growth and fixation in areas of increased risk of mechanical stress. This is a fundamentally important adaptive mechanism for strengthening the tendon tissue, acting in advance.

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Funding

This work was performed with financial support of the State Program of Scientific Research “Chemical Processes, Reagents, and Technologies, Bioregulators, and Bioorganic Chemistry” under task 2.1.04.7 for 2021–2025.

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Authors and Affiliations

  1. Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus, Minsk, Belarus

    A. A. Gaidash, V. K. Krut’ko, A. I. Kulak & O. N. Musskaya

  2. Research Institute for Physical Chemical Problems, Belarusian State University, Minsk, Belarus

    K. V. Skrotskaya

  3. Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus

    Yu. P. Tokalchik & V. A. Kulchitsky

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  1. A. A. Gaidash
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  2. V. K. Krut’ko
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  5. K. V. Skrotskaya
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Correspondence to A. A. Gaidash.

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The authors declare that they have no conflicts of interest.

The authors did not conduct experiments with human participation. All procedures performed in animal research comply with the ethical standards of the National Committee for Research Ethics and the Helsinki Declaration on Bioethics and Human Rights (WMA Declaration of Helsinki—Ethical Principles for Medical Research Involving Human Subjects, 2013).

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Gaidash, A.A., Krut’ko, V.K., Kulak, A.I. et al. Structure of the Peritenons of the Paravertebral Tendons Treated with Hyaluronic Acid. Biol Bull Rev 13, 559–571 (2023). https://doi.org/10.1134/S2079086423060075

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