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Application of SC-CO2 in the Technology of the Preparation of Calcium Phosphate Matrices for the Treatment of Septic Purulent Inflammations of Bone Tissues

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Abstract

Based on carbonate-substituted hydroxyapatite (HAP) containing vancomycin, a method is developed for the preparation of macroporous matrices that combine bioresorbability, osteoconductivity, and the possibility for the volumetric impregnation of antibiotics without loss of their activity and their prolonged release. The technology includes treatment with supercritical CO2 as the final stage in the preparation of a matrix, which makes it possible to completely remove the organic solvent that serves as an extractant for the pore formation additive, i.e., polyethylene glycol (PEG) granules, and to increase the biocompatibility of the matrix, as confirmed by the results of histological tests during subcutaneous implantation. The activity of vancomycin after its volumetric incorporation into the calcium phosphate matrix is demonstrated in the regions of inhibiting the growth of bacterial cultures. As proven in in vivo experiments on the implantation of bones, the matrix is a therapeutically effective carrier of antibacterial substances in the treatment of septic purulent inflammations of bone tissues.

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Funding

This study was financially supported by the Russian Foundation for Basic Research (project no. 18-29-06010) and technologically supported by LLC IPK LIK.

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Authors and Affiliations

  1. National Medical Research Center for Traumatology and Orthopedics named after N.N. Priorov, Ministry of Health of the Russian Federation, Moscow, Russia

    Yu. S. Lukina & N. S. Gavryushenko

  2. Mendeleev University of Chemical Technology of Russia, Moscow, Russia

    Yu. S. Lukina

  3. Chemical Faculty, Moscow State University, Moscow, Russia

    L. V. Panova, Yu. M. Panov, D. P. Krut’ko & D. A. Lemenovskii

Authors
  1. Yu. S. Lukina
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  2. L. V. Panova
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  3. Yu. M. Panov
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  4. D. P. Krut’ko
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  5. N. S. Gavryushenko
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  6. D. A. Lemenovskii
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Correspondence to Yu. S. Lukina or D. A. Lemenovskii.

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Translated by O. Kadkin

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Lukina, Y.S., Panova, L.V., Panov, Y.M. et al. Application of SC-CO2 in the Technology of the Preparation of Calcium Phosphate Matrices for the Treatment of Septic Purulent Inflammations of Bone Tissues. Russ. J. Phys. Chem. B 16, 1221–1230 (2022). https://doi.org/10.1134/S1990793122070120

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  • DOI: https://doi.org/10.1134/S1990793122070120

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