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Kinetics of Release of the TEMPONE Nitroxyl Radical from Poly-D,L-Lactide Foamed in the Supercritical Carbon Dioxide Medium

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Abstract—The electron spin resonance method was used to quantitatively describe the release of a paramagnetic bioactive substance from a biodegradable polymer matrix. A standard spin probe TEMPONE was chosen as the paramagnetic compound and poly-D,L-lactide foamed in supercritical carbon dioxide (SC–CO2) was used as the polymer. The release of TEMPONE from a porous poly-D,L-lactide to phosphate buffer saline (pH 7.4) was shown to occur gradually (without periods of burst and stagnation), which suggests that the used process of polymer impregnation and foaming can be applied to design materials for medical purposes.

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Funding

This work was supported in part by Moscow State University Program of Development. The authors acknowledge the financial support of the Russian Foundation for Basic Research (grants no. 17-02-00445 and no. 18-29-06059).

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Authors and Affiliations

  1. Faculty of Chemistry, Moscow State University, 119991, Moscow, Russia

    T. A. Ivanova, N. A. Chumakova, E. N. Golubeva & V. V. Lunin

  2. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    E. N. Golubeva & V. V. Lunin

Authors
  1. T. A. Ivanova
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  2. N. A. Chumakova
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  3. E. N. Golubeva
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  4. V. V. Lunin
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Correspondence to T. A. Ivanova.

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Translated by K. Utegenov

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Ivanova, T.A., Chumakova, N.A., Golubeva, E.N. et al. Kinetics of Release of the TEMPONE Nitroxyl Radical from Poly-D,L-Lactide Foamed in the Supercritical Carbon Dioxide Medium. Russ. J. Phys. Chem. B 13, 1211–1213 (2019). https://doi.org/10.1134/S199079311907025X

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  • DOI: https://doi.org/10.1134/S199079311907025X

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