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EPR Diagnostics of D,L-Polylactide Porous Matrices Formed in Supercritical CO2

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Abstract

The regularities of formation of D,L-polylactide porous matrices in supercritical CO2 environment with simultaneous impregnation with paramagnetic biologically active 4-hydroxy-2,2,6,6-tetramethylpiperidine- 1-oxyl (TEMPOL) was studied using spin probe electron paramagnetic resonance (EPR) and optical microscopy. The dependence of the average and local concentration of a dopant on impregnation conditions was assessed. The resulting matrices meet important requirements for porous materials for tissue engineering. Considering that impregnation of a polymer with a paramagnetic compound makes it possible to study the uniform distribution of a dopant in a sample at macroscopic and microscopic levels and to study a structure of a polymer matrix, EPR spectroscopy is a promising method for studying porous polymeric materials formed under supercritical conditions.

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Authors and Affiliations

  1. Moscow State University, Moscow, Russia

    N. A. Chumakova, E. N. Golubeva & T. A. Ivanova

  2. Institute of Photonic Technologies, Crystallography and Photonics Research Center, Russian Academy of Sciences, Moscow, Russia

    N. N. Vorobieva, P. S. Timashev & V. N. Bagratashvili

  3. Institute for Regenerative Medicine, Sechenov University, Moscow, Russia

    P. S. Timashev

Authors
  1. N. A. Chumakova
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  2. E. N. Golubeva
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  3. T. A. Ivanova
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  4. N. N. Vorobieva
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  5. P. S. Timashev
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  6. V. N. Bagratashvili
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Corresponding author

Correspondence to N. A. Chumakova.

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Original Russian Text © N.A. Chumakova, E.N. Golubeva, T.A. Ivanova, N.N. Vorobieva, P.S. Timashev, V.N. Bagratashvili, 2018, published in Sverkhkriticheskie Flyuidy. Teoriya i Praktika, 2018, Vol. 13, No. 1, pp. 86–93.

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Chumakova, N.A., Golubeva, E.N., Ivanova, T.A. et al. EPR Diagnostics of D,L-Polylactide Porous Matrices Formed in Supercritical CO2. Russ. J. Phys. Chem. B 12, 1255–1260 (2018). https://doi.org/10.1134/S1990793118080031

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  • DOI: https://doi.org/10.1134/S1990793118080031

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