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Regeneration of jejunal wall defect using an implant based on silk fibroin fibers

  • Biochemistry, Biophysics, and Molecular Biology
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Abstract

Regenerative properties of fibroin implant vitalized with allogeneic bone marrow cells were assessed. The study was performed using the experimental model of rat jejunum wall damage. Three weeks after surgery, we observed recovery of all layers of the jejunum wall at the site of injury and complete degradation of the implant material.

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References

  1. Warner, B.W., Tissue engineered small intestine: a viable clinical option?, Ann. Surg., 2004, vol. 240, no. 5, pp. 755–756.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Grikscheit, T.C., Siddique, A., Ochoa, E.R., Srinivasan, A., Alsberg, E., Hodin, R.A., and Vacanti, J.P., Tissue-engineered small intestine improves recovery after massive small bowel resection, Ann. Surg., 2004, vol. 240, no. 5, pp. 748–754.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Badylak, S., Meurling, S., Chen, M., Spievack, A., and Simmons-Byrd, A., Resorbable bioscaffold for esophageal repair in a dog model, J. Pediatr. Surg., 2000, vol. 35, no. 7, pp. 1097–1103.

    Article  CAS  PubMed  Google Scholar 

  4. Moisenovich, M.M., Malyuchenko, N.V., Arkhipova, A.Yu., Goncharenko, A.V., Kotlyarova, M.S., Davydova, L.I., Vasil’eva, T.V., Bogush, V.G., Agapov, I.I., Debabov, V.G., and Kirpichnikov, M.P., Recombinant 1F9 spidroin microgels for murine fullthickness wound repairing, Dokl. Biochem. Biophys., 2016, vol. 466, pp. 9–12.

    Article  CAS  PubMed  Google Scholar 

  5. Moisenovich, M.M., Malyuchenko, N.V., Arkhipova, A.Yu., Kotlyarova, M.S., Davydova, L.I., Goncharenko, A.V., Agapova, O.I., Drutskaya, M.S., Bogush, V.G., Agapov, I.I., Debabov, V.G., and Kirpichnikov, M.P., Novel 3D-microcarriers from recombinant spidroin for regenerative medicine, Dokl. Biochem. Biophys., 2015, vol. 463, pp. 232–235.

    Article  CAS  PubMed  Google Scholar 

  6. Moisenovich, M.M., Kulikov, D.A., Arkhipova, A.Y., Malyuchenko, N.V., Kotlyarova, M.S., Goncharenko, A.V., Kulikov, A.V., Mashkov, A.E., Agapov, I.I., Paleev, F.N., Svistunov, A.A., and Kirpichnikov, M.P., Fundamental bases for the use of silk fibroin-based bioresorbable microvehicles as an example of skin regeneration in therapeutic practice, Ter. Arkhiv., 2015, vol. 87, no. 12, pp. 66–72.

    Article  CAS  Google Scholar 

  7. Moisenovich, M.M., Arkhipova, A.Y., Orlova, A.A., Drutskaya, M.S., Volkova, S.V., Zacharov, S.E., Agapov, I.I., and Kirpichnikov, M.P., Composite scaffolds containing silk fibroin, gelatin, and hydroxyapatite for bone tissue regeneration and 3D cell culturing, Acta Naturae, 2014, vol. 6, pp. 96–101.

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Vacanti, J.P., Morse, M.A., Saltzman, W.M., Domb, A.J., Perez-Atayde, A., and Langer, R., Selective cell transplantation using bioabsorbable artificial polymers as matrices, J. Pediatr. Surg., 1988, vol. 23, no. 1, pp. 3–9.

    Article  CAS  PubMed  Google Scholar 

  9. Choi, R.S. and Vacanti, J.P., Preliminary studies of tissue-engineered intestine using isolated epithelial organoid units on tubular synthetic biodegradable scaffolds, Transplant. Proc., 1997, vol. 9, nos. 1/2, pp. 848–851.

    Article  Google Scholar 

  10. Körbling, M., Katz, R.L., Khanna, A., Ruifrok, A.C., Rondon, G., Albitar, M., Champlin, R.E., and Estrov, Z., Hepatocytes and epithelial cells of donor origin in recipients of peripheral-blood stem cells, N. Engl. J. Med., 2002, vol. 346, no. 10, pp. 738–746.

    Article  PubMed  Google Scholar 

  11. Krause, D.S., Theise, N.D., Collector, M.I., Henegariu, O., Hwang, S., Gardner, R., Neutzel, S., and Sharkis, S.J., Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell, Cell, 2001, vol. 105, no. 3, pp. 369–377.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to M. M. Moisenovich.

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Original Russian Text © M.M. Moisenovich, D.A. Kulikov, A.V. Goncharenko, A.Y. Arkhipova, T.V. Vasiljeva, Yu.N. Filyushkin, L.V. Arkhipova, M.S. Kotlyarova, A.V. Kulikov, A.E. Mashkov, I.I. Agapov, M.P. Kirpichnikov, 2017, published in Doklady Akademii Nauk, 2017, Vol. 472, No. 2, pp. 219–221.

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Moisenovich, M.M., Kulikov, D.A., Goncharenko, A.V. et al. Regeneration of jejunal wall defect using an implant based on silk fibroin fibers. Dokl Biochem Biophys 472, 12–14 (2017). https://doi.org/10.1134/S1607672917010045

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  • DOI: https://doi.org/10.1134/S1607672917010045

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