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A Novel pH-Responsive Magnetic Nanosystem for Delivery of Anticancer Drugs

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Abstract

A novel pH-responsive magnetic nanosystem was designed and developed for cancer therapy. For this purpose, a well-defined terpolymer was synthesized through the polymerization of 2-hydroxyethyl methacrylate (HEMA) monomer using reversible addition fragmentation chain transfer (RAFT) technique and simultaneous grafting of ε-caprolactone (ε-CL) monomer via ring-opening polymerization (ROP) approach followed by block copolymerization of acrylic acid (AA) monomer via RAFT polymerization method, in order to produce a poly(acrylic acid)-block-[poly(2-oxyethyl methacrylate)-grafted-poly(ε-caprolactone)] [PAA-b-(POEMA-g-PCL)]. Afterward, magnetite nanoparticles (Fe3O4 NPs) were synthesized through chemical co-precipitation method, and then incorporated into the developed terpolymer through physical interactions (e.g., electrostatic and hydrogen bonding) via solution mixing approach. The doxorubicin hydrochloride (Dox), as an anticancer model drug, loading (LE) and encapsulation (EE) efficiencies of the fabricated magnetic nanosystem were calculated to be 96 ± 5 and 9.65 ± 0.5%, respectively. The drug release study results revealed that the developed drug delivery system (DDS) could be efficiently control the delivery of Dox in response to pH stimuli.

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REFERENCES

  1. J. Hu, S. Youssefian, J. Obayemi, K. Malatesta, N. Rahbar, and W. Soboyejo, Acta Biomater. 71, 363 (2018).

    Article  CAS  Google Scholar 

  2. D. Hanahan and R. A. Weinberg, Cell 144, 646 (2011).

    CAS  Google Scholar 

  3. A. M. Bode and Z. Dong, Nat. Rev. Cancer 9, 508 (2009),

    Article  CAS  Google Scholar 

  4. A. Wicki, D. Witzigmann, V. Balasubramanian, and J. Huwyler, J. Controlled Release 200, 138 (2015).

    Article  CAS  Google Scholar 

  5. W. Park, A. C. Gordon, S. Cho, X. Huang, K. R. Harris, A. C. Larson, and D. H. Kim, ACS Appl. Mater. Interfaces 9, 13819 (2017).

    Article  CAS  Google Scholar 

  6. A. Espinosa, R. Di Corato, J. Kolosnjaj-Tabi, P. Flaud,T. Pellegrino, and C. Wilhelm, ACS Nano 10, 2436 (2016).

    Article  CAS  Google Scholar 

  7. M. Frank, C. B. Borkner, M. Toro-Nahuelpan, H. M. Herold, D. S. Maier, J. M. Plitzko,T. Scheibel, and D. Schüler, Biomacromolecules 19, 962 (2018).

    Article  Google Scholar 

  8. K. Soleiman, E. Arkana, H. Derakhshankhah, B. Haghshenas, R. Jahanban-Esfahlan, M. Jaymand, Carbohydr. Polym. 252, 117229 (2021).

    Article  Google Scholar 

  9. A. A. Tregubov, I. L. Sokolov, A. V. Babenyshev, P. I. Nikitin,V. R. Cherkasov, and M. P. Nikitin, J. Magn. Magn. Mater. 449, 590 (2018).

    Article  CAS  Google Scholar 

  10. A. Farnoudian-Habibi, S. Kangari, B. Massoumi, and M. Jaymand, RSC Adv. 5, 102895 (2015).

  11. J. T. Jang, H. Nah, J. H. Lee, S. H. Moon, M. G. Kim, J. Cheon, Angew. Chim., Int. Ed. 48, 1234 (2009).

    Article  CAS  Google Scholar 

  12. A. Jafarizad, A. Taghizadehgh-Alehjougi, M. Eskandani, M. Hatamzadeh, M. Abbasian, R. Mohammad-Rezaei, M. Mohammadzadeh, B. Togar, and M. Jaymand, Bio-Med. Mater. Eng. 29, 177 (2018).

    Article  CAS  Google Scholar 

  13. Z. Mozafari, B. Massoumi, and M. Jaymand, Polym. -Plast. Technol. Eng. 58, 405 (2019).

    CAS  Google Scholar 

  14. L. H. Reddy, J. L. Arias, J. Nicolas, and P. Couvreur, Chem. Rev. 112, 5818 (2012).

    Article  CAS  Google Scholar 

  15. N. Poorgholy, B. Massoumi, and M. Jaymand, Int. J. Biol. Macromol. 97, 654 (2017).

    Article  CAS  Google Scholar 

  16. H. **ong,Y. Wu, Z. Jiang, J. Zhou, M. Yang, and J. Yao, J. Colloid Interface Sci. 536, 135 (2019).

    Article  CAS  Google Scholar 

  17. W. Lin, N. Yao, L. Qian, X. Zhang, Q. Chen, J. Wang, and L. Zhang, Acta Biomater. 58, 455 (2017).

    Article  CAS  Google Scholar 

  18. D. Schmaljohann, Adv. Drug Delivery Rev. 58, 1655 (2006).

    Article  CAS  Google Scholar 

  19. S. Mura, J. Nicolas, and P. Couvreur, Nat. Mater. 12, 991 (2013).

    Article  CAS  Google Scholar 

  20. F. Mahmoodzadeh, M. Abbasian, M. Jaymand, and A. Amirshaghaghi, Polym. Int. 66, 1651 (2017).

    Article  CAS  Google Scholar 

  21. A. Ghamkhari, B. Massoumi, and M. Jaymand, Des. Monomer Polym. 20, 190 (2017).

    Article  CAS  Google Scholar 

  22. P. Chmielarz, M. Fantin, S. Park, A. A. Isse, A. Gennaro, A. J. Magenau, and K. Matyjaszewski, Prog. Polym. Sci. 69, 47 (2017).

    Article  CAS  Google Scholar 

  23. G. Moad, Polym. Chem. 8, 177 (2017).

    Article  CAS  Google Scholar 

  24. X. G. Qiao, O. Lambert, J. C. Taveau, P. Y. Dugas, B. Charleux, M. Lansalot, and E. Bourgeat-Lami, Macromolecules 50, 3796 (2017).

    Article  CAS  Google Scholar 

  25. M. Abbasian, M. Judi, F. Mahmoodzadeh, and M. Jaymand, Polym. Adv. Technol. 29, 3097 (2018).

    Article  CAS  Google Scholar 

  26. D. J. Keddie, Chem. Soc. Rev. 43, 496 (2014).

    Article  CAS  Google Scholar 

  27. S. Perrier, P. Takolpuckdee, and C. A. Mars, Macromolecules 38, 2033 (2005).

    Article  CAS  Google Scholar 

  28. B. Massoumi, S. V. Mousavi-Hamamlu, A. Ghamkhari, and M. Jaymand, Polym.-Plast. Technol. Eng. 56, 873 (2017).

    Article  CAS  Google Scholar 

  29. B. Massoumi, Z. Mozaffari, and M. Jaymand, Int. J. Biol. Macromol. 117, 418 (2018).

    Article  CAS  Google Scholar 

  30. R. Kulkarni, R. Boppana, G. Krishna-Mohan, S. Mutalik, and N. V. Kalyane, J. Colloid Interface Sci. 367, 509 (2012).

    Article  CAS  Google Scholar 

  31. T. Jiang, Z. Zhang, Y. Zhang, H. Lv, J. Zhou, C. Li, L. Hou, and Q. Zhang, Biomaterials 33, 9246 (2012).

    Article  CAS  Google Scholar 

  32. M. Jaymand, ACS Biomater. Sci. Eng. 6, 134 (2020).

    Article  CAS  Google Scholar 

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Funding

The authors gratefully acknowledge the partial financial support from Payame Noor University, Tehran, Iran, and Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

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Authors and Affiliations

  1. Department of Chemistry, Payame Noor University, Tehran, Iran

    Nazila Taghavi & Bakhshali Massoumi

  2. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

    Mehdi Jaymand

Authors
  1. Nazila Taghavi
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  2. Bakhshali Massoumi
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  3. Mehdi Jaymand
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Corresponding authors

Correspondence to Bakhshali Massoumi or Mehdi Jaymand.

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Nazila Taghavi, Massoumi, B. & Jaymand, M. A Novel pH-Responsive Magnetic Nanosystem for Delivery of Anticancer Drugs. Polym. Sci. Ser. B 63, 408–417 (2021). https://doi.org/10.1134/S1560090421040102

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