Abstract
Multilayer microcapsules with the encapsulated model drug (acetylsalicylic acid) are formed by the layer-by-layer adsorption of natural polysaccharides, chitosan and sodium carboxymethyl cellulose, onto microparticles of calcium carbonate. Three encapsulation methods are considered: physical adsorption of acetylsalicylic acid in the pores of calcium carbonate microparticles, coprecipitation of an acid with an inorganic template material during its preparation, and incorporation of an acid into hollow capsules by varying the permeability of their shells. To vary the shell permeability, it is proposed to change the polarity of the solvent by introducing 50 vol% ethanol into an aqueous solution. The method has the highest efficiency in encapsulation of acetylsalicylic acid and does not allow the release of acid from the capsules in acidic environments.
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GPM (General Pharmacopoeia Monograph). 1.4.2.0014.15. Dissolution for solid dosage forms. State Pharmacopoeia of the Russian Federation, Moscow, 2018, XIV ed.
REFERENCES
Shah, A., Aftab, S., Iftikhar, F.J., Nisar, J., and Ashiq, M.N., J. Drug. Deliv. Sci. Tec., 2021, vol. 62, ID 102426. https://doi.org/10.1016/j.jddst.2021.102426
Wohl, B.M., and Engbersen, J.F.J., J. Control. Release, 2012, vol. 158, no. 1, pp. 2–14. https://doi.org/10.1016/j.jconrel.2011.08.035
Campbell, J. and Vikulina, A.S., Polymers, 2020, vol. 12, no. 9, ID 1949. https://doi.org/10.3390/polym12091949
Alkekhia, D., Shukla, D.A., and Hammond, P.T., Annu. Rev. Biomed. Eng., 2020, vol. 22, ID 32084319. https://doi.org/10.1146/annurev-bioeng-060418-052350
Zhao, D., Yu, S., Sun, B., Gao, S., Guo, S., and Zhao, K., Polymers, 2018, vol. 10, no. 4, pp. 462–479. https://doi.org/10.3390/polym10040462
Victor, R.S., Santos, A.M.C., Sousa, B.V., Neves, G.A., Santana, L.N.L., and Menezes, R.R., Materials, 2020, vol. 13, no. 21, ID 33171898. https://doi.org/10.3390/ma13214995
Parhi, R., Environ. Chem. Lett., 2020, vol. 18, no. 3, pp. 577–594. https://doi.org/10.1007/s10311-020-00963-5
Palamarchuk, I.A., Brovko, O.S., Bogolitsyn, K.G., Boitsova, T.A., Ladesov, A.V., and Ivakhnov, A.D., Russ. J. Appl. Chem., 2015, vol. 88, no. , pp. 103–109. https://doi.org/10.1134/S1070427215010152
Shilova, S.V., Zinurova, O.A., Tret’yakova, A.Y., and Barabanov, V.P., Russ. J. Appl. Chem., 2014, vol. 87, no. 3, pp. 315−323. https://doi.org/10.1134/S1070427214030124
Quadrado, R.F.N., and Fajardo, A.R., Arab. J. Chem., 2020, vol. 13, no. 1, pp. 2183−2194. https://doi.org/10.1016/j.arabjc.2018.04.004
L’vov, Y., Antipov, A.A., Mamedov, A., Möhwald, H., and Sukhorukov, G.B., Nanoletters, 2001, vol. 1, no. 3, pp. 125–128. https://doi.org/10.1021/nl0100015
Sukhorukov, G.B., Volodkin, D.V., Gunther, A.M., Petrov, A.I., Shenoy, D.B., and Mohwald H., J. Mater. Chem., 2004, vol. 14, pp. 2073–2081. https://doi.org/10.1039/B402617A
Volodkin, D., Adv. Colloid Interface Sci., 2014, vol. 207, pp. 306–324. https://doi.org/10.1016/j.cis.2014.04.001
Biesheuvel, P.M., and Stuart, М.А.С., Langmuir, 2004, vol. 20, pp. 2785−2791. https://doi.org/10.1021/la036204l
Ferjaoui, Z., Nahle, S., Chang, C.S., Ghanbaja, J., Joubert, O., Schneider, R., Ferrari, L., Gaffet, E., and Alem, H., ACS Omega, 2020, vol. 5, no. 10, pp. 4770–4777. https://doi.org/10.1021/acsomega.9b02963
Kabanov, V.A., Russ. Chem. Rev., 2005, vol. 74, no. 1, pp. 3–20. https://doi.org/10.1070/RC2005v074n01ABEH001165
Krayukhina, M.A., Samoilova, N.A., and Yamskov, I.A., Russ. Chem. Rev., 2008, vol. 77, no. 9, pp. 799–813. https://doi.org/10.1070/RC2008v077n09ABEH003750
Reichardt, C., Solvents and Solvent Effects in Organic Chemistry, New York: Wiley, 1988.
Shilova, S.V., Mirgaleev, G.M., Tret’yakova, A.Ya., and Barabanov, V.P., Polym. Sci. Ser. A, 2020, vol. 62, no. 6, pp. 630−635. https://doi.org/10.1134/S0965545X20050156
Mendelson, J., Barrett, C., Chan, V., Pal, A., Mayes, A., and Rubner, M., Langmuir, 2000, vol. 16, pp. 5017–5023. https://doi.org/10.1021/la000075g
Popova, A.P., Korneeva, I.N., Savchenko, I.A., Bondarenko, D.Ya., Antonov, I.A., and Komarovskii, I.V., Mezhdunar. Zh. Prikl. Fundam. Issled., 2016, no. 7, pp. 592–596.
Mudarisova, R.Kh., Kulish, E.I., Zinatullin, R.M., Tamindarova, N.E., Kolesov, S.V., Khunafin, S.N., and Monakova, Y.B., Russ. J. Appl. Chem., 2006, vol. 79, no. 7, pp. 1210−1212. https://doi.org/10.1134/S1070427206070354
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Translated from Zhurnal Prikladnoi Khimii, No. 7, pp. 882–888, January, 2021 https://doi.org/10.31857/S0044461821070093
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Shilova, S.V., Mirgaleev, G.M., Tretyakova, A.Y. et al. Comparison of Methods for Encapsulation of Acetyl Salicylic Acid in Polyelectrolyte Capsules Based on Chitosan. Russ J Appl Chem 94, 934–939 (2021). https://doi.org/10.1134/S1070427221070107
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DOI: https://doi.org/10.1134/S1070427221070107