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Investigation of the Process of Obtaining Chitosan-Based Aerogel Particles with Impregneated Lidocaine Hydrochloride for the Development of Local Hemostatic Agents with an Anesthetic Effect

  • Selected articles originally published in Russian in Rossiiskii Khimicheskii Zhurnal (Russian Chemistry Journal)
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Abstract

In the present article chitosan-based aerogel particles with the impregnated lidocaine hydrochloride via supercritical adsorption method were studied. During the research particles of 1% chitosan aerogel were obtained by the drip** method. Drying of the obtained gels was carried out in a supercritical fluid. The impregnation of lidocaine hydrochloride into the pores of the chitosan-based aerogel was carried out by supercritical adsorption with varying process temperature. The article presents the schemes of apparatuses for the drying process and supercritical adsorption. Using the method of high-performance liquid chromatography, the amount of impregnated drug in the obtained aerogel samples was determined. The sorption capacity of the obtained particles was determined using a solution simulating blood, Earle’s Balanced Salt Solution. It was found that the samples have a sorption capacity comparable to the sorption capacity of aerogel particles without impregnated lidocaine hydrochloride. Using X-ray phase analysis, the state of the drug in the pores of the chitosan-based aerogel was investigated. In the course of the research work a release kinetics of lidocaine hydrochloride from aerogel particles was also obtained using a dissolution tester Sotax AT 7 Smart, the “rotating paddle” method. The results of the conducted analytical studies demonstrate that when an active pharmaceutical ingredients is impregnated into aerogel particles by supercritical adsorption, it is possible to obtain a local hemostatic agent with a therapeutic anesthetic effect and a controlled dosage of the active pharmaceutical substance to relieve pain when used.

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Funding

The work was financially supported by D. Mendeleev University of Chemical Technology of Russia, an applied research project of young full-time employees of D. Mendeleev University of Chemical Technology of Russia within the framework of the strategic academic leadership program “Priority 2030” No. VIG-2022-007.

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  1. Mendeleev University of Chemical Technology of Russia, 125047, Moscow, Russia

    D. S. Komarova, K. M. Demkin, M. S. Mochalova & D. D. Lovskaya

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  1. D. S. Komarova
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  2. K. M. Demkin
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  3. M. S. Mochalova
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  4. D. D. Lovskaya
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Correspondence to D. S. Komarova.

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Komarova, D.S., Demkin, K.M., Mochalova, M.S. et al. Investigation of the Process of Obtaining Chitosan-Based Aerogel Particles with Impregneated Lidocaine Hydrochloride for the Development of Local Hemostatic Agents with an Anesthetic Effect. Russ J Gen Chem 93, 3251–3257 (2023). https://doi.org/10.1134/S1070363223120265

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