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The search for new candidate genes involved in ovarian cancer pathogenesis by exome sequencing

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Abstract

Ovarian cancer is one of the most insidious of tumors among gynecological cancers in the world. BRCA1 and BRCA2 mutations are associated with high risk of ovarian cancer; however, they are causative only in a fraction of cases. The search for new genes would expand our understanding of the mechanisms underlying malignant ovarian tumors and could help to develop new methods of early diagnosis and treatment of the disease. The present study involved exome sequencing of eight DNA samples extracted from the blood of ovarian cancer patients. As a result of the study, 53057 modifications in one sample were identified on average. Of them, 222 nucleotide sequence modifications in DNA located in exons and splice sites of 203 genes were selected. On the basis of the function of these genes in the cell and their involvement in carcinogenesis, 40 novel candidate genes were selected. These genes are involved in cell cycle control, DNA repair, apoptosis, regulation of cell invasion, proliferation and growth, transcription, and also immune response and might be involved in development of ovarian cancer.

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Authors and Affiliations

  1. Bashkir State University, Ufa, 450074, Russia

    D. S. Prokofyeva, E. T. Mingajeva & E. K. Khusnutdinova

  2. Clinics of Obstetrics and Gynecology, Hannover Medical School, Hannover, 30625, Germany

    N. V. Bogdanova & T. Dörk

  3. Clinical Oncology Center, Ufa, 450054, Russia

    R. R. Faiskhanova & D. D. Sakaeva

  4. Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of Sciences, Ufa, 450054, Russia

    E. K. Khusnutdinova

Authors
  1. D. S. Prokofyeva
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  2. E. T. Mingajeva
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  3. N. V. Bogdanova
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  4. R. R. Faiskhanova
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  5. D. D. Sakaeva
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  6. T. Dörk
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  7. E. K. Khusnutdinova
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Corresponding author

Correspondence to D. S. Prokofyeva.

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Original Russian Text © D.S. Prokofyeva, E.T. Mingajeva, N.V. Bogdanova, R.R. Faiskhanova, D.D. Sakaeva, T. Dörk, E.K. Khusnutdinova, 2016, published in Genetika, 2016, Vol. 52, No. 10, pp. 1215–1221.

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Prokofyeva, D.S., Mingajeva, E.T., Bogdanova, N.V. et al. The search for new candidate genes involved in ovarian cancer pathogenesis by exome sequencing. Russ J Genet 52, 1105–1109 (2016). https://doi.org/10.1134/S102279541609012X

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  • DOI: https://doi.org/10.1134/S102279541609012X

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