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Physicochemical and Toxicological Studies of the Polymorphic Modifications of the Rodenticidal Substance “Chlorophacinone”

  • BIOPHYSICAL CHEMISTRY AND PHYSICAL AND CHEMICAL BIOLOGY
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Abstract

The results of studies of the polymorphism of the rodenticidal substance 2-[(4-chlorophenyl)phenylacetyl]-1H-indene-1,3(2H)-dione “chlorophacinone”, which has an anticoagulant mechanism of action, are presented. Methods for the synthesis of two new polymorphic forms (III and IV) have been established, for which data from physicochemical studies (IR, XRD) and information on the biological activity (toxicity) of polymorphs are given. Both forms crystallize in the monoclinic crystal system with space group P21/с and the following unit cell parameters: a = 16.698(1) Å, b = 5.632(1) Å, c = 20.253(2) Å, β = 109.65(1)° for III; and a = 9.853(1) Å, b = 9.041(1) Å, c = 20.474(1) Å, β = 97.322(3)° for IV. Polymorphic form IV with a toxicity parameter DL50 (gray rats) of 0.47 mg/kg has the highest biological activity versus 2.74 mg/kg for the less active form III. A method of identification of the most active form (IV) by IR spectroscopy was proposed.

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Funding

The X-ray diffraction studies were performed using the equipment purchased due to the grant of the Moscow University Development Program.

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Authors and Affiliations

  1. Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    A. N. Kochetov, L. A. Nosikova, Z. A. Kudryashova, V. V. Chernyshev & A. Yu. Tsivadze

  2. Moscow State University, 119991, Moscow, Russia

    V. V. Chernyshev & V. A. Tafeenko

  3. Russian Technological University (Institute of Fine Chemical Technologies, MIREA), 119571, Moscow, Russia

    A. Yu. Tsivadze

Authors
  1. A. N. Kochetov
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  2. L. A. Nosikova
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  3. Z. A. Kudryashova
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  4. V. V. Chernyshev
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  5. V. A. Tafeenko
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  6. A. Yu. Tsivadze
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Correspondence to A. N. Kochetov.

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Translated by L. Smolina

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Kochetov, A.N., Nosikova, L.A., Kudryashova, Z.A. et al. Physicochemical and Toxicological Studies of the Polymorphic Modifications of the Rodenticidal Substance “Chlorophacinone”. Russ. J. Phys. Chem. 97, 1335–1343 (2023). https://doi.org/10.1134/S0036024423060109

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  • DOI: https://doi.org/10.1134/S0036024423060109

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