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Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand

  • STRUCTURAL–FUNCTIONAL ANALYSIS OF BIOPOLYMERS AND THEIR COMPLEXES
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Abstract

Using a computer modeling approach, we proposed a structure for a potential GC-specific DNA ligand, which could form a complex with DNA in the minor groove similar to that formed by Hoechst 33258 at DNA AT-enriched sites. According to this model, MBoz2A, a bisbenzoxazole ligand, was synthesized. The results of spectrophotometric methods supported the complex formation of the compound under study with DNA differing in the nucleotide composition.

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Funding

This work was supported by the Russian Science Foundation, project no. 23-24-00082.

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991, Moscow, Russia

    A. F. Arutyunyan, M. S. Aksenova, A. A. Stomakhin, D. N. Kaluzhny & A. L. Zhuze

  2. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 119334, Moscow, Russia

    A. A. Kostyukov

Authors
  1. A. F. Arutyunyan
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  2. M. S. Aksenova
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  3. A. A. Kostyukov
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  4. A. A. Stomakhin
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  5. D. N. Kaluzhny
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  6. A. L. Zhuze
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Correspondence to A. L. Zhuze.

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The original online version of this article was revised: Modifications have been made to the author’s name and Fig. 1. Full information regarding the corrections made can be found in the erratum/correction for this article.

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Arutyunyan, A.F., Aksenova, M.S., Kostyukov, A.A. et al. Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand. Mol Biol 58, 547–556 (2024). https://doi.org/10.1134/S0026893324700171

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  • DOI: https://doi.org/10.1134/S0026893324700171

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