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The NKG2 natural killer cell receptor family: comparative analysis of promoter sequences

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Abstract

The NKG2 receptor family is crucially involved in target cell recognition by natural killer cells and comprises several activating as well as inhibitory family members. We have established approximately 3 kilobases of upstream promoter sequences of the human NKG2-C, -E and -F genes and have carried out a comparative analysis with available NKG2-A sequences. We found extended regions of homology which contain numerous putative transcription factor binding sites conserved in the NKG2 genes. However, variation in Alu insertion among family members has led to promoter structures unique to the respective family members, which could contribute to differences in transcriptional initiation as well as gene-specific regulation.

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Author notes

  1. F Francis

    Present address: Institut Cochin de Génétique Moléculaire, Unité 129 de l’Inserm, CHU Cochin-Port-Royal, 24 Rue du Faubourg Saint Jacques, Paris, F-75014, France

Authors and Affiliations

  1. Department of Surgery, Vienna General Hospital 8G9.05, University of Vienna, Währinger Gürtel 18–20, Vienna, A-1090, Austria

    C Brostjan

  2. Department of Vascular Biology and Thrombosis Research, Vienna International Research Cooperation Center, University of Vienna, Brunnerstraße 59, Vienna, A-1235, Austria

    Y Sobanov, S Hayer & E Hofer

  3. Max-Planck-Institute for Molecular Genetics, Ihnesstraße 73, Berlin, D-14195, Germany

    J Glienke, H Lehrach & F Francis

Authors
  1. C Brostjan
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  2. Y Sobanov
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  3. J Glienke
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  4. S Hayer
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  5. H Lehrach
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  6. F Francis
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  7. E Hofer
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Corresponding author

Correspondence to E Hofer.

Additional information

This work was supported in part by grants from the Austrian National Bank (Jubiläumsfonds No 7567) and the European Commission (BIO-CT95–0062).

The nucleotide sequence data reported in this paper have been submitted to the GenBank / EMBL nucleotide sequence databases and have been assigned the accession numbers AF238468 (NKG2-C), AF238469 (NKG2-E) and AF238470 (NKG2-F).

According to the Human Gene Nomenclature Database (www.gene.ucl.ac.uk/nomenclature) the various gene loci described in this manuscript have obtained the following symbols: KLRC1 (NKG2-A/-B), KLRC2 (NKG2-C), KLRC3 (NKG2-E/-H), KLRC4 (NKG2-F) and KLRD1 (CD94).

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Brostjan, C., Sobanov, Y., Glienke, J. et al. The NKG2 natural killer cell receptor family: comparative analysis of promoter sequences. Genes Immun 1, 504–508 (2000). https://doi.org/10.1038/sj.gene.6363715

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  • DOI: https://doi.org/10.1038/sj.gene.6363715

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