Abstract
This case report shows reversible brain MRI changes probably associated with acyclovir toxicity. So far, neuroimaging in acyclovir toxicity had been negative or uninformative. A 12-year-old girl developed focal secondary generalizing epileptic fits following 4 weeks of prophylactic administration of acyclovir (3 × 10 mg/kg body weight/day i.v.) on day +22 after allogeneic peripheral blood stem cell transplantation for CML. Infective causes were excluded. Brain MRI demonstrated multiple gadolinium-enhancing areas with impairment of the blood–brain barrier in cortical and subcortical regions. Clinical symptoms and neuroimaging pathology resolved completely within 9 days of acyclovir withdrawal.
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Blohm, M., Nürnberger, W., Aulich, A. et al. Reversible brain MRI changes in acyclovir neurotoxicity. Bone Marrow Transplant 19, 1049–1051 (1997). https://doi.org/10.1038/sj.bmt.1700790
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DOI: https://doi.org/10.1038/sj.bmt.1700790
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