IL-1R1 signaling in neural stem cells reduces hippocampal neurogenesis in adult mice, potentially affecting learning and memory. Using a new mouse model, we report that IL-1β drives cognitive impairment after infection with SARS-CoV-2, and that IL-1β-driven cognitive impairment can be prevented by vaccination, even in cases of breakthrough infection.
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This is a summary of: Vanderheiden, A. et al. Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice. Nat. Immunol. https://doi.org/10.1038/s41590-024-01868-z (2024).
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Vaccination prevents cognitive impairment after breakthrough infection with SARS-CoV-2. Nat Immunol 25, 1136–1137 (2024). https://doi.org/10.1038/s41590-024-01869-y
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DOI: https://doi.org/10.1038/s41590-024-01869-y
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