Extended Data Fig. 2: Single cell RNA sequencing UMAP plots of cells from replicate recipients of single Vwf-tdTomato⁺ P-HSC or Vwf-tdTomato⁻ Multi-HSC.

Batch corrected UMAP plots of LIN⁻cKIT + cells replenished by a single transplanted Vwf-tdTomato⁺ P-HSC (7 recipient mice; P1-7) or Vwf-tdTomato⁻ Multi-HSC (8 recipient mice; M1-8). Colors indicate molecularly defined HSCs (red), MkPs (blue), and other cells (green). Mice used for RNA sequencing do not overlap with mice in Supplementary Tables 1–3.