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Flip** hemagglutinin on its head

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Antigen reorientation via oligoD, a label-free, alum-based technique, guides immunofocused, broadly reactive antibody responses.

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Fig. 1: HA antigen configurations bound to alum adjuvant via oligoD.

References

  1. Ward, A. B. & Wilson, I. A. Curr. Opin. Immunol. 65, 50–56 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Krammer, F. Nat. Rev. Immunol. 19, 383–397 (2019).

    Article  CAS  PubMed  Google Scholar 

  3. Bernstein, D. I. et al. Lancet Infect. Dis. 20, 80–91 (2020).

    Article  CAS  PubMed  Google Scholar 

  4. Arevalo, C. P. et al. Science 378, 899–904 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Moin, S. M. et al. Immunity 55, 2405–2418.e7 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Xu, D. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-023-01529-6 (2024).

    Article  PubMed  Google Scholar 

  7. Brewer, J. M. Immunol. Lett. 102, 10–15 (2006).

    Article  CAS  PubMed  Google Scholar 

  8. Verma, S. K. et al. Front. Immunol. 14, 1043109 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Moyer, T. J. et al. Nat. Med. 26, 430–440 (2020).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Turner, H. L. et al. STAR Protoc. 4, 102476 (2023).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to James A. Ferguson.

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Ferguson, J.A., Han, J. & Ward, A.B. Flip** hemagglutinin on its head. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-024-01545-0

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