Transporters and channels have strong potential as drug targets, but drug discovery targeting these membrane-embedded molecules is challenging. Fragment-based ligand discovery combined with chemical proteomics offers a promising solution to the search for inhibitors of solute transporter family members.
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Toyama-Sorimachi, N. Sinking the carrier. Nat Chem Biol (2024). https://doi.org/10.1038/s41589-023-01540-x
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DOI: https://doi.org/10.1038/s41589-023-01540-x
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