Extended Data Fig. 13: Comparison of chromatin accessibility (CA) conserved and divergent cCREs between mouse and human.

a, A schematic of CA conserved and divergent cCREs. The CA-conserved cCREs are the cCREs in our snATAC-seq data that are conserved across species and have open chromatin in orthologous regions. The CA divergent cCREs are sequence conserved to orthologous regions but have not been identified as open chromatin regions in other species. The bar plot shows the numbers of CA-conserved and CA-divergent cCREs. b, Bar plot showing the relative fraction of CA conserved and divergent cCREs across subclasses. c, Radar chart showing the fraction of genomic distribution of CA-conserved and CA-divergent cCREs. The CA-conserved cCREs show an increase in percentage in Promoter-TSS regions. d, Histograms showing the number of CA-conserved and CA-divergent cCREs in subclasses. The number of CA-conserved cCREs is higher than CA-divergent cCREs. e, Histograms showing the CA-conserved cCREs captured by the number of cell subclasses. A fraction of CA-conserved cCREs are captured by more than 200 cell subclasses. f, Histograms showing the CA-divergent cCREs captured by the number of cell subclasses. Most CA-divergent cCREs are captured by less than 50 cell subclasses.