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A mammalian pexophagy target

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Protein ubiquitylation in mammals is known to trigger selective autophagy of peroxisomes through a process termed pexophagy. The physiological peroxisomal target for pexophagy-related ubiquitylation has been controversial, but two studies have now identified the protein PEX5 as the real candidate.

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Figure 1: Protein modifications on H. sapiens PEX5L (long isoform) that regulate pexophagy.
Figure 2: Signalling of pexophagy by ROS, hypoxia and inhibition of PEX5 export from peroxisomes.

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Acknowledgements

S.S. is supported by NIH grant DK41737.

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  1. Division of Biological Sciences, Suresh Subramani is in the Section of Molecular Biology, University California, San Diego, California 92093-0322, USA,

    Suresh Subramani

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  1. Suresh Subramani
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Correspondence to Suresh Subramani.

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Subramani, S. A mammalian pexophagy target. Nat Cell Biol 17, 1371–1373 (2015). https://doi.org/10.1038/ncb3253

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