Extended Data Figure 2: Protein domain structure of functionally tested human disease genes.
From: Identification of cis-suppression of human disease mutations by comparative genomics
a, Schematic of BBS4 (519 amino acids) is depicted with eight tetratricopeptide (TPR) domains (yellow); b, RPGRIP1L (1,315 amino acids) has multiple coiled-coil domains (green rectangles) and two protein kinase C conserved region 2 (C2) domains (green hexagons); and c, BTG2 (158 amino acids) has one BTG1 domain (purple pentagon). Disease-causing alleles are shown with red stars; complementing alleles are represented with blue stars; amino acid number scale in increments of 100 is shown below each schematic.