Extended Data Figure 5: Epigenetic priming.

This figure relates to Fig. 5 in the main text. a, TERA scores for H3K27ac, H3K4me3, H3K4me1 and DNAme for transcription factors showing evidence of priming (top, bold) and transcription factors predicted to significantly co-occur in these primed binding sites. b, Gene expression levels shown as z scores for primed and co-binding transcription factors from panel a. c, Detailed predicted co-binding relationship (P ≤ 0.01, enrichment ≥ 1.5) of primed transcription factors (columns) with significantly associated co-binding factors (rows). d, Illustration of a potential priming event and the associated predicted target gene at the ATOH1 locus (chromosome 4: 94,740–94,800). For each stage, H3K27ac, H3K27me3 and DNAme patterns are shown along with predicted NEUROD binding sites (black boxes) in putative gene regulatory elements marked by a loss of DNAme (highlighted by the grey bars). e, Gene set enrichment analysis results for predicted NEUROD binding sites split up by dynamic patterns defined in the top of Fig. 5b. Binding sites in patterns 3 and 4 showed no significant enrichment.