SpringerLink
Log in

Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parenteral nutrition

  • Short Communication
  • Published:
European Journal of Clinical Nutrition Submit manuscript

Abstract

Emerging evidence suggests taurolidine reduces the risk of repeated episodes of catheter related blood stream infections (CRBSI) in a subgroup of patients receiving home parenteral nutrition (HPN). We defined 3 indications where taurolidine could be considered and retrospectively analysed data from patients who were treated over a 10 year period to examine the validity of these criteria. Twenty-two patients were identified from a total HPN population of 81, representing 33.2 years of experience. The overall CRBSI rate pre- and post-taurolidine usage was reduced from 5.71 to 0.99 infections per 1000 patient parenteral nutrition days (P-value <0.0001), with reductions identified in each smaller subgroup, confirming previous reports of a significant reduction in infections when taurolidine is used as secondary prophylaxis and providing initial data suggesting the benefit of its use as primary prophylaxis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price includes VAT (Germany)

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Toure A, Lauverjat M, Peraldi C, Boncompain-Gerard M, Gelas P, Barnoud D et al. Taurolidine lock solution in the secondary prevention of central venous catheter-associated bloodstream infection in home parenteral nutritionpatients. Clin Nutr 2012; 31: 567–570.

    Article  CAS  Google Scholar 

  2. Bisseling TM, Willems MC, Versleijen MW, Hendriks JC, Vissers RK, Wanten GJ . Taurolidine lock is highly effective in preventing catheter-related bloodstream infections in patients on home parenteral nutrition: a heparin-controlled prospective trial. Clin Nutr 2010; 29: 464–468.

    Article  CAS  Google Scholar 

  3. Cullis PS, McKee RF . Taurolidine lock - experience from the West of Scotland. Clin Nutr 2011; 30: 399–400; author reply 1.

    Article  Google Scholar 

  4. Santarpia L, Alfonsi L, Tiseo D, Creti R, Baldassarri L, Pasanisi F et al. Central venous catheter infections and antibiotic therapy during long-term home parenteral nutrition: an 11-year follow-up study. JPEN J Parenter Enteral Nutr 2010; 34: 254–262.

    Article  Google Scholar 

  5. Ugur A, Marashdeh BH, Gottschalck I, Brobech Mortensen P, Staun M, Bekker Jeppesen P . Home parenteral nutrition in Denmark in the period from 1996 to 2001. Scand J Gastroenterol 2006; 41: 401–407.

    Article  Google Scholar 

  6. Benoit JL, Carandang G, Sitrin M, Arnow PM . Intraluminal antibiotic treatment of central venous catheter infections in patients receiving parenteral nutrition at home. Clin Infect Dis 1995; 21: 1286–1288.

    Article  CAS  Google Scholar 

  7. Fortun J, Grill F, Martin-Davila P, Blazquez J, Tato M, Sanchez-Corral J et al. Treatment of long-term intravascular catheter-related bacteraemia with antibiotic-lock therapy. J Antimicrob Chemother 2006; 58: 816–821.

    Article  CAS  Google Scholar 

  8. Fernandez-Hidalgo N, Almirante B, Calleja R, Ruiz I, Planes AM, Rodriguez D et al. Antibiotic-lock therapy for long-term intravascular catheter-related bacteraemia: results of an open, non-comparative study. J Antimicrob Chemother 2006; 57: 1172–1180.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Southampton NIHR Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK

    J Saunders, M Naghibi, C Parsons, T Smith & M Stroud

  2. Department of Nutrition and Dietetics, University Hospital Southampton, Southampton, UK

    Z Leach

  3. Department of Surgery, University Hospital Southampton, Southampton, UK

    A King

Authors
  1. J Saunders
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M Naghibi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Z Leach
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C Parsons
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A King
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. T Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. M Stroud
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M Stroud.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Additional information

Contributors: JS conceived the study, carried out the study, data analysis and drafted the manuscript. MN carried out the study, data analysis and helped draft the manuscript. MN carried out the study, data analysis and helped draft the manuscript. ZL carried out data collection and helped draft the manuscript. CP carried out data analysis and performed statistical analysis. AK conceived the study, participated in its design and coordination and helped write the manuscript. TS conceived the study, participated in its design and coordination and helped write the manuscript. MS conceived the study, participated in its design and coordination and helped write the manuscript (guarantor of article). All authors approved the final version of the article including the authorship list.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Saunders, J., Naghibi, M., Leach, Z. et al. Taurolidine locks significantly reduce the incidence of catheter-related blood stream infections in high-risk patients on home parenteral nutrition. Eur J Clin Nutr 69, 282–284 (2015). https://doi.org/10.1038/ejcn.2014.32

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ejcn.2014.32

  • Springer Nature Limited

Search

Navigation